透明质酸局部应用对上颌后牙种植体稳定性的影响:临床和动物研究。

IF 1.7 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Merna Hosny Elhadidi, Eman Abdel Salam Yousef, Menatalla M Elhindawy, Wael Mohammed Said Ahmed
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引用次数: 0

摘要

目的:评价局部应用透明质酸(HA)对上颌骨后即刻加载种植体稳定性的影响。材料和方法:在临床研究中,14名患者共植入了20颗种植体,以寻找缺失的单颗或多颗上颌后牙的替代品。患者被随机分为两组。在临床对照组(CC组)中,10个植入物被放置并立即加载,而在临床研究组(CS组),10个种植物在放置前立即涂上HA并立即加载。所有患者在植入物放置时间(T0)和加载后1(T1)、3(T3)和6(T6)个月进行了植入物稳定性的临床评估。在6个月时对所有患者的种植体周围袋深度和改良的沟出血指数进行临床评估。3个月后进行骨密度评估。对所有临床和放射学数据进行统计分析。在动物研究中,共有12个植入物被放置在6只兔子的胫骨中。对于每只兔子,在左胫骨中放置1个未施加任何HA的植入物(AC组),在右胫骨中放置一个涂有HA的植入体(AS组)。在植入物后21天和45天对兔子实施安乐死。结果:两组在种植体稳定性、种植体周围袋深度、改良沟出血指数或腭部和根尖部骨密度方面没有显著的统计学差异。然而,颊侧的骨密度有显著的统计学差异,有利于研究组。动物研究表明,与左胫骨相比,右胫骨新形成的骨具有更致密的骨小梁和更小的骨髓间隙,因此骨的数量和质量都有所改善。结论:在临床研究中,透明质酸的应用对即刻加载的种植体周围的颊骨密度有较好的影响。在动物研究中,透明质酸对种植牙周围骨形成的质量和数量具有协同作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Topical Application of Hyaluronic Acid on the Stability of Immediate Loaded Dental Implants in the Posterior Maxilla: Clinical and Animal Study.

Objective: To assess the effect of topically applied hyaluronic acid (HA) on the stability of immediately loaded implants in the posterior maxilla. Materials and Methods: For the clinical study, a total of 20 implants were placed in 14 patients seeking the replacement of missing single or multiple posterior maxillary teeth. The patients were randomly divided into two groups. In the clinical control group (CC group), 10 implants were placed and immediately loaded, while in the clinical study group (CS group), 10 implants were coated with HA immediately before placement and immediately loaded. All patients had implant stability clinically evaluated at implant placement time (T0) and 1 (T1), 3 (T3), and 6 (T6) months after loading. Peri-implant pocket depth and modified sulcus bleeding index were evaluated clinically at 6 months in all patients. Bone density was evaluated radiographically after 3 months. All the clinical and radiographic data were subjected to statistical analysis. For the animal study, a total of 12 implants were placed in the tibiae of six rabbits. For each rabbit, 1 implant without any applied HA was placed in the left tibia (AC group), and 1 implant coated with HA was placed in the right tibia (AS group). The rabbits were euthanized at 21 and 45 days after implant insertion. Results: There were no significant statistical differences between the two groups regarding implant stability, peri-implant pocket depth, modified sulcus bleeding index, or bone density from the palatal and apical aspects. However, there was a significant statistical difference in the bone density from the buccal aspect in favor of the study group. The animal study showed that the newly formed bone in the right tibiae showed improved quantity and quality of bone, as it had denser bone trabeculae and smaller marrow spaces compared to the left tibiae. Conclusion: In the clinical study, the application of hyaluronic acid had a superior effect on the buccal bone density around immediately loaded implants. In the animal study, hyaluronic acid had a synergistic effect on the quality and quantity of bone formation around dental implants.

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来源期刊
CiteScore
3.30
自引率
5.00%
发文量
115
审稿时长
6 months
期刊介绍: Edited by Steven E. Eckert, DDS, MS ISSN (Print): 0882-2786 ISSN (Online): 1942-4434 This highly regarded, often-cited journal integrates clinical and scientific data to improve methods and results of oral and maxillofacial implant therapy. It presents pioneering research, technology, clinical applications, reviews of the literature, seminal studies, emerging technology, position papers, and consensus studies, as well as the many clinical and therapeutic innovations that ensue as a result of these efforts. The editorial board is composed of recognized opinion leaders in their respective areas of expertise and reflects the international reach of the journal. Under their leadership, JOMI maintains its strong scientific integrity while expanding its influence within the field of implant dentistry. JOMI’s popular regular feature "Thematic Abstract Review" presents a review of abstracts of recently published articles on a specific topical area of interest each issue.
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