Ahmad Piroozmand, Batool Zamani, Hamed Haddad Kashani, Javad Amini Mahabadi
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The disease duration and activity, C-reactive protein (CRP), chest x-ray and highresolution CT scan (HRCT) findings, ejection fraction (EF) and echocardiography findings, and pulmonary artery pressure (PAP) were also determined in both groups.</p><p><strong>Results: </strong>The age of patients in case and control groups was 52.5 ± 9.3 and 43.9 ± 9.7 years, respectively (p = 0.001). No significant difference was found between serum levels of IL-6 in case and control groups (73.1 ± 95.4 vs 46.7 ± 83.6 pg/ml, p = 0.267). However, IL-6 level was significantly higher in male case patients compared to male controls (p = 0.007). The duration of PSS was 11.6 ± 6.4 and 7.4 ± 4.2 years in case and control groups, respectively (p = 0.002). The quantitative CRP and PAP was also significantly higher in case patients (p = 0.01 and p < 0.001, respectively). There was found reticulonodular pattern in 20 (66.7%) of the cases, whereas 28 (93.3%) of the controls had normal Chest X-rays (CXR) (p < 0.001). 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引用次数: 0
摘要
背景:原发性系统性硬化症(PSS)是一种结缔组织疾病,其特征是皮肤和内脏中过多的胶原沉积。间质性肺疾病(ILD)是PSS的晚期表现,细胞因子可参与疾病病理。本研究的目的是确定进行性系统性硬化症患者血清白细胞介素-6水平与肺受累之间的关系。方法和材料:在知情同意的情况下,对30例伴有肺受累的PSS患者(病例组)和30例无肺受累的PSS患者(对照组)进行人口统计学资料和血清白细胞介素-6水平的测定。同时测定两组患者的病程和活动度、c反应蛋白(CRP)、胸部x线和高分辨率CT扫描(HRCT)、射血分数(EF)和超声心动图表现以及肺动脉压(PAP)。结果:病例组和对照组患者年龄分别为52.5±9.3岁和43.9±9.7岁(p = 0.001)。病例组与对照组血清IL-6水平差异无统计学意义(73.1±95.4 vs 46.7±83.6 pg/ml, p = 0.267)。然而,男性患者的IL-6水平明显高于男性对照组(p = 0.007)。病例组和对照组PSS持续时间分别为11.6±6.4年和7.4±4.2年(p = 0.002)。结论:血清IL-6水平与肺部受累无相关性,不能作为潜在的治疗靶点。
Serum interleukin-6 level and its association with pulmonary involvement in progressive systemic sclerosis; a case-control study.
Background: Primary Systemic Sclerosis (PSS) is a connective tissue disorder characterized by excessive collagen deposition in the skin and internal organs. Interstitial lung disease (ILD) is a late demonstration of PSS and cytokines can contribute to the disease pathology. The purpose of the current study was to determine the association between serum interleukin-6 level and pulmonary involvement in progressive systemic sclerosis.
Methods and materials: Demographic data and serum interleukin-6 levels were measured for 30 PSS patients with pulmonary involvement (case group) and 30 PSS patients without pulmonary involvement (control group) following informed consent. The disease duration and activity, C-reactive protein (CRP), chest x-ray and highresolution CT scan (HRCT) findings, ejection fraction (EF) and echocardiography findings, and pulmonary artery pressure (PAP) were also determined in both groups.
Results: The age of patients in case and control groups was 52.5 ± 9.3 and 43.9 ± 9.7 years, respectively (p = 0.001). No significant difference was found between serum levels of IL-6 in case and control groups (73.1 ± 95.4 vs 46.7 ± 83.6 pg/ml, p = 0.267). However, IL-6 level was significantly higher in male case patients compared to male controls (p = 0.007). The duration of PSS was 11.6 ± 6.4 and 7.4 ± 4.2 years in case and control groups, respectively (p = 0.002). The quantitative CRP and PAP was also significantly higher in case patients (p = 0.01 and p < 0.001, respectively). There was found reticulonodular pattern in 20 (66.7%) of the cases, whereas 28 (93.3%) of the controls had normal Chest X-rays (CXR) (p < 0.001). EF was significantly lower in case patients compared to control patients (p = 0.001).
Conclusion: The serum level of IL-6 did not appear to have a relationship with pulmonary involvement, hence it could not be regarded as a potential therapeutic target.
期刊介绍:
Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.