为当地控制西尼罗河病毒,部署伊维菌素处理的喂鸟器可减少传播。

IF 3 3区 医学 Q2 INFECTIOUS DISEASES
Karen M. Holcomb , Chilinh Nguyen , Nicholas Komar , Brian D. Foy , Nicholas A. Panella , Marissa L. Baskett , Christopher M. Barker
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引用次数: 0

摘要

伊维菌素(IVM)处理的鸟类有可能有针对性地控制库蚊,以减少西尼罗河病毒(WNV)的传播。IVM的摄入增加了蚊子的死亡率,这可以减少WNV从鸟类向人类的传播,并减少主要影响以鸟类为食的蚊子和从鸟类向人的地方病维持周期。这一策略还可能为控制西尼罗河病毒提供一种替代方法,减少杀虫剂耐药性和大规模杀虫剂应用后勤的阻碍。通过实地研究和建模相结合,我们评估了在居民区部署IVM处理的鸟饲料以减少WNV传播的可行性和影响。我们首先使用无线电遥测和射频识别追踪了105只鸟类,以监测它们的喂食器使用情况和夜间栖息地的位置,这与科罗拉多州科林斯堡附近的五个喂食器位置有关。利用这些结果,我们修改了WNV传播的分区模型,以考虑IVM对蚊子死亡率以及鸟类和蚊子在社区水平上的空间运动的影响。我们发现,虽然一个社区中处理地块的数量对总传播潜力有很大影响,但一个社区内处理地块的排列几乎没有影响。无论WNV能力状况如何,增加接受治疗的鸟类的比例,都比只治疗有能力的鸟类更能降低感染动态。总之,模型结果表明,部署经IVM处理的喂食器可以减少整个WNV季节的局部传播,包括减少人类感染爆发前的地方病传播,蚊子的空间覆盖率和IVM诱导的死亡率很高。为了改进预测,还需要做更多的工作来完善对城市地区蚊子每日移动和IVM引起的死亡率的估计。我们的研究结果可以指导该控制策略的未来现场试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Predicted reduction in transmission from deployment of ivermectin-treated birdfeeders for local control of West Nile virus

Predicted reduction in transmission from deployment of ivermectin-treated birdfeeders for local control of West Nile virus

Ivermectin (IVM)-treated birds provide the potential for targeted control of Culex mosquitoes to reduce West Nile virus (WNV) transmission. Ingestion of IVM increases mosquito mortality, which could reduce WNV transmission from birds to humans and in enzootic maintenance cycles affecting predominantly bird-feeding mosquitoes and from birds to humans. This strategy might also provide an alternative method for WNV control that is less hampered by insecticide resistance and the logistics of large-scale pesticide applications. Through a combination of field studies and modeling, we assessed the feasibility and impact of deploying IVM-treated birdfeed in residential neighborhoods to reduce WNV transmission. We first tracked 105 birds using radio telemetry and radio frequency identification to monitor their feeder usage and locations of nocturnal roosts in relation to five feeder sites in a neighborhood in Fort Collins, Colorado. Using these results, we then modified a compartmental model of WNV transmission to account for the impact of IVM on mosquito mortality and spatial movement of birds and mosquitoes on the neighborhood level. We found that, while the number of treated lots in a neighborhood strongly influenced the total transmission potential, the arrangement of treated lots in a neighborhood had little effect. Increasing the proportion of treated birds, regardless of the WNV competency status, resulted in a larger reduction in infection dynamics than only treating competent birds. Taken together, model results indicate that deployment of IVM-treated feeders could reduce local transmission throughout the WNV season, including reducing the enzootic transmission prior to the onset of human infections, with high spatial coverage and rates of IVM-induced mortality in mosquitoes. To improve predictions, more work is needed to refine estimates of daily mosquito movement in urban areas and rates of IVM-induced mortality. Our results can guide future field trials of this control strategy.

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来源期刊
Epidemics
Epidemics INFECTIOUS DISEASES-
CiteScore
6.00
自引率
7.90%
发文量
92
审稿时长
140 days
期刊介绍: Epidemics publishes papers on infectious disease dynamics in the broadest sense. Its scope covers both within-host dynamics of infectious agents and dynamics at the population level, particularly the interaction between the two. Areas of emphasis include: spread, transmission, persistence, implications and population dynamics of infectious diseases; population and public health as well as policy aspects of control and prevention; dynamics at the individual level; interaction with the environment, ecology and evolution of infectious diseases, as well as population genetics of infectious agents.
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