采用间接法计算甲状腺疾病的参考区间,并与参考变化值进行比较。

IF 3.8 3区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Zeynep Yildiz, Lale Köroğlu Dağdelen
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引用次数: 1

摘要

本研究的目的是计算促甲状腺激素(TSH)、游离甲状腺素(fT4)和游离三碘甲状腺原氨酸(fT3)的参考区间(RIs),并利用分析物的参考变化值(RCV)评价这些区间的临床意义。材料和方法:对2021年8月至12月的实验室患者数据进行评估。共评价188,912例患者TSH、fT4、fT3、抗甲状腺过氧化物酶抗体(Anti-TPO)和抗甲状腺球蛋白抗体(Anti-Tg)结果。所有测量均采用电化学发光免疫分析技术在Cobas c801 (Roche Diagnostics, Penzberg, Germany)上进行。通过分析物的rcv将估计的RIs与制造商的RIs进行比较。结果:促甲状腺激素值在性别、年龄上无显著差异。全组(N = 28,437)的综合RIs为0.41 ~ 4.37 mIU/mL。游离T4值(11.6 ~ 20.1 pmol/L, N = 13,479);10.5 ~ 19.5 pmol/L,女性N = 17,634)和fT3值(3.38 ~ 6.35 pmol/L,男性N = 2,516;3.39 ~ 5.99 pmol/L,女性N = 3348 pmol/L),性别差异显著(P < 0.050)。fT4和fT3值在年龄亚组比较中也显示出显著差异。因此,男性和女性RIs分别代表年龄亚组。与制造商的RIs相比,TSH全组和fT4亚组的RIs没有超过分析者的rcv,但fT3的差异更大。结论:利用实验室数据外的间接方法估计参考区间可能比制造商提供的RIs更准确。使用分析物的RCV评估基于人群的RIs可能为实验室结果的临床解释提供有用的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Reference intervals for thyroid disorders calculated by indirect method and comparison with reference change values.

Reference intervals for thyroid disorders calculated by indirect method and comparison with reference change values.

Reference intervals for thyroid disorders calculated by indirect method and comparison with reference change values.

Introduction: The aim of the study was to calculate reference intervals (RIs) for thyroid stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) and evaluate the clinical significance of these intervals by use of reference change values (RCV) of the analytes.

Materials and methods: Laboratory patient data between August and December 2021 were evaluated for the study. A total of 188,912 patients with TSH, fT4, fT3, anti-thyroid peroxidase antibodies (Anti-TPO) and anti-thyroglobulin antibodies (Anti-Tg) results were evaluated. All measurements were performed on Cobas c801 (Roche Diagnostics, Penzberg, Germany) using electrochemiluminescence immunoassay technology. Estimated RIs were compared with manufacturer's by means of RCVs of analytes.

Results: Thyroid stimulating hormone values didn't differ significantly by gender and age. The combined RIs for whole group (N = 28,437) was found as 0.41-4.37 mIU/mL. Free T4 values (11.6-20.1 pmol/L, N = 13,479 in male; 10.5-19.5 pmol/L, N = 17,634 female) and fT3 values (3.38-6.35 pmol/L, N = 2,516 in male; 3.39-5.99 pmol/L, N = 3,348 pmol/L in female) significantly differed by gender (P < 0.050). Both fT4 and fT3 values also showed significant differences in age subgroups comparisons. So, male and female RIs were represented separately for age subgroups. When compared with manufacturer's RIs, TSH whole group and fT4 subgroups RIs didn't exceed the analytes' RCVs, but this difference was greater for fT3.

Conclusions: Reference interval estimation by use of indirect method out of laboratory data may be more accurate than manufacturer provided RIs. This population based RIs evaluated using RCV of analytes may provide useful information in clinical interpretation of laboratory results.

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来源期刊
Biochemia Medica
Biochemia Medica 医学-医学实验技术
CiteScore
5.50
自引率
3.00%
发文量
70
审稿时长
>12 weeks
期刊介绍: Biochemia Medica is the official peer-reviewed journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Journal provides a wide coverage of research in all aspects of clinical chemistry and laboratory medicine. Following categories fit into the scope of the Journal: general clinical chemistry, haematology and haemostasis, molecular diagnostics and endocrinology. Development, validation and verification of analytical techniques and methods applicable to clinical chemistry and laboratory medicine are welcome as well as studies dealing with laboratory organization, automation and quality control. Journal publishes on a regular basis educative preanalytical case reports (Preanalytical mysteries), articles dealing with applied biostatistics (Lessons in biostatistics) and research integrity (Research integrity corner).
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