创伤后应激障碍的额叶α不对称:抑制控制任务中创伤后应激障碍和非创伤后应激障碍个体的组差异。

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Clinical EEG and Neuroscience Pub Date : 2023-09-01 Epub Date: 2021-10-16 DOI:10.1177/15500594211046703
Teresa López-Castro, Laura Martin, Sean Nickley, Tanya C Saraiya, Robert D Melara
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引用次数: 2

摘要

目前的研究检查了在有或没有创伤暴露和创伤后应激障碍(PTSD)的参与者中,额叶α不对称(FAA)作为接近和回避相关的前额叶活动的标志。我们在两种认知需求水平下研究了抑制控制范式(威胁性与非威胁性线索)下的FAA(基线:一组试验中的图像恒定;对比过滤:三组参与者的图像在一个区域内随机变化:有创伤后应激障碍的个体(n = 16),暴露于创伤但没有创伤后应激障碍(n = 14),和没有创伤后应激障碍或创伤暴露的对照组(n = 15)。在低需求(基线)条件下,PTSD和创伤暴露的受试者对威胁性图像的相对左额叶活动明显大于右额叶活动(接近)。在高要求(过滤)条件下,威胁性和非威胁性图像之间没有FAA差异,但创伤后应激障碍参与者的相对左侧FAA多于右侧FAA,而创伤暴露参与者的相对左侧FAA减少。在所有条件下,健康对照组表现出相对于右FAA减少,威胁和非威胁图像之间没有差异。研究结果表明,创伤后应激障碍患者存在功能失调的前额叶情绪调节机制,而非创伤后应激障碍患者存在适应性的前额叶情绪调节机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Frontal Alpha Asymmetry in Posttraumatic Stress Disorder: Group Differences Among Individuals With and Without PTSD During an Inhibitory Control Task.

The current study examined frontal alpha asymmetry (FAA) as a marker of approach- and avoidance-related prefrontal activity in participants with and without trauma exposure and posttraumatic stress disorder (PTSD). We investigated FAA in an inhibitory control paradigm (threatening vs nonthreatening cues) under 2 levels of cognitive demand (baseline: images constant within a block of trials; vs filtering: images varied randomly within a block) in 3 groups of participants: individuals with PTSD (n = 16), exposed to trauma but without PTSD (n = 14), and a control group without PTSD or trauma exposure (n = 15). Under low demand (baseline), both PTSD and trauma-exposed participants exhibited significantly greater relative left than right frontal brain activity (approach) to threatening than to nonthreatening images. Under high demand (filtering), no FAA differences were found between threatening and nonthreatening images, but PTSD participants revealed more relative left than right FAA, whereas trauma-exposed participants showed reduced left relative right FAA. In all conditions, healthy controls exhibited reduced left relative to right FAA and no differences between threatening and nonthreatening images. Study findings suggest dysfunctional prefrontal mechanisms of emotion regulation in PTSD, but adaptive prefrontal regulation in trauma-exposed individuals without PTSD.

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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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