可逆钙调磷酸酶抑制剂相关的感觉运动多发性神经病在肺移植受体:一个病例报告。

IF 0.3 Q4 TRANSPLANTATION

International Journal of Organ Transplantation Medicine Pub Date : 2021-01-01

T Antychin, J A Zarowski, V Verplancke, J M H Hendriks, S K Yogeswaran, P Lauwers, K Lamote, J M Kwakkel-van Erp

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引用次数: 0

摘要

钙调磷酸酶抑制剂(CNIs)被认为是实体器官移植后免疫抑制治疗的基石。然而，神经毒性是CNIs的一个常见副作用，可导致广泛的神经系统症状，如头痛、震颤和癫痫发作。在本病例报告中，我们描述了一位患者，他在双侧肺移植后出现了与CNI相关的严重运动和感觉神经元功能障碍，在停止CNI并切换到哺乳动物靶向雷帕霉素抑制剂后，这种功能障碍得到了解决。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Reversible Calcineurin Inhibitor-associated Sensorimotor Polyneuropathy in a Lung Transplant Recipient: A Case Report.

Calcineurin inhibitors (CNIs) are regarded as a corner stone in immunosuppressive therapy after solid organ transplantation. However, neurotoxicity is a common side effect of CNIs, resulting in a wide range of neurological symptoms such as headache, tremor and seizures. In this case report, we describe a patient who developed severe motor and sensory neuron dysfunction related to CNIs after bilateral lung transplantation, which resolved after halting CNI and switching to a mammalian Target of Rapamycin-inhibitor.

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来源期刊

International Journal of Organ Transplantation Medicine TRANSPLANTATION-

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The International Journal of Organ Transplantation Medicine (IJOTM) is a quarterly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research on transplantation. The scope of the journal includes organ and tissue donation, procurement and preservation; surgical techniques, innovations, and novelties in all aspects of transplantation; genomics and immunobiology; immunosuppressive drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses in the field of transplantation; transplant complications; cell and tissue transplantation; infection; post-transplant malignancies; sociological and ethical issues and xenotransplantation.