染色质结构从发育到老化。

Q1 Biochemistry, Genetics and Molecular Biology

Sub-cellular biochemistry Pub Date : 2023-01-01 DOI:10.1007/978-3-031-21410-3_2

Lorelei Ayala-Guerrero, Sherlyn Claudio-Galeana, Mayra Furlan-Magaril, Susana Castro-Obregón

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引用次数: 1

摘要

核结构影响基因组结构，这有助于确定基因表达模式。在发育和分化过程中，染色质动力学的全局变化是必不可少的，也是衰老的标志之一。本章描述了发育和衰老过程中染色质结构的分子动力学。在第一部分中，我们介绍了基因组的核层、染色质结构和三维组织的一般信息。接下来，我们详细介绍了在发育和衰老过程中发现的分子标志，包括DNA和组蛋白修饰的作用，3D基因组动力学和核层的变化。在本章中，我们讨论了基因组结构对驱动发育和衰老机制的影响，以及当这些机制失效时的生理后果。

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Chromatin Structure from Development to Ageing.

Nuclear structure influences genome architecture, which contributes to determine patterns of gene expression. Global changes in chromatin dynamics are essential during development and differentiation, and are one of the hallmarks of ageing. This chapter describes the molecular dynamics of chromatin structure that occur during development and ageing. In the first part, we introduce general information about the nuclear lamina, the chromatin structure, and the 3D organization of the genome. Next, we detail the molecular hallmarks found during development and ageing, including the role of DNA and histone modifications, 3D genome dynamics, and changes in the nuclear lamina. Within the chapter we discuss the implications that genome structure has on the mechanisms that drive development and ageing, and the physiological consequences when these mechanisms fail.

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来源期刊

Sub-cellular biochemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

5.90

自引率

0.00%

发文量

期刊介绍： The book series SUBCELLULAR BIOCHEMISTRY is a renowned and well recognized forum for disseminating advances of emerging topics in Cell Biology and related subjects. All volumes are edited by established scientists and the individual chapters are written by experts on the relevant topic. The individual chapters of each volume are fully citable and indexed in Medline/Pubmed to ensure maximum visibility of the work.