p53作为示例性下一代免疫组织化学标记物：一种分子知情、基于模式的方法、方法学考虑因素和泛癌诊断应用。

IF 1.3 4区医学 Q3 ANATOMY & MORPHOLOGY

Applied Immunohistochemistry & Molecular Morphology Pub Date : 2023-08-01 Epub Date: 2023-07-21 DOI:10.1097/PAI.0000000000001144

Andrew M Bellizzi

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引用次数: 0

摘要

这篇综述是基于我在2022年2月为国际免疫组织化学和分子形态学学会（ISIMM）举办的网络研讨会。所有ISIMM网络研讨会最终都将作为评论文章发表在AIMM上。这部作品也是献给克莱夫·泰勒的，他深深地影响了我的职业生涯。它为p53免疫组织化学解释、方法考虑（即抗体选择、优化、验证、对照和外部质量评估）和全癌诊断应用提供了一种分子知情、基于模式的方法，包括来自胃肠道、泌尿生殖道、妇科、神经内分泌、血液学和神经病理学的应用。它旨在证明p53是一种典型的下一代免疫组织化学标记物，它早于时代“诞生”。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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p53 as Exemplar Next-Generation Immunohistochemical Marker: A Molecularly Informed, Pattern-Based Approach, Methodological Considerations, and Pan-Cancer Diagnostic Applications.

This review is based on a webinar I presented for the International Society for Immunohistochemistry and Molecular Morphology (ISIMM) in February 2022. It is intended that all ISIMM webinars will ultimately be published in AIMM as review articles. This work is also dedicated to Clive Taylor, who has deeply impacted my career. It presents a molecularly informed, pattern-based approach to p53 immunohistochemistry interpretation, methodological considerations (ie, antibody selection, optimization, validation, controls, and external quality assessment), and pan-cancer diagnostic applications, including those drawn from gastrointestinal, genitourinary, gynecological, neuroendocrine, hematologic, and neuropathology. It intends to prove the thesis statement that p53 is an exemplar next-generation immunohistochemical marker "born" ahead of its time.

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来源期刊

Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY

CiteScore

3.20

自引率

0.00%

发文量

153

期刊介绍： Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology.