探索蛛网膜下腔出血的治疗方法。

Journal of biomed research Pub Date : 2022-01-01
Mohammad Reza Hosseini Siyanaki, Brandon Lucke-Wold, Majid Khan
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引用次数: 0

摘要

蛛网膜下腔出血(SAH)仍然是发病率和死亡率的主要原因,脑血管痉挛是导致临床恶化的常见病因。本研究旨在评估和回顾有关 SAH 有效治疗的现有文献。随着新治疗靶点的确定,SAH 的治疗方案也在不断扩大。尼莫地平具有神经保护作用,是主要的处方药。此外,某些药物(如右美托咪定、SSRIs 和 DL-3-n-butylphthalide 等)可促进淋巴流动并影响恢复过程。血管痉挛和缺血患者通常会接受腔内球囊血管成形术。临床试验尚未提供支持使用镁或他汀类药物的确凿证据。此外,还应进一步研究其他药物,如钙通道阻滞剂、米力农、硫化氢、外泌体、促红细胞生成素、西洛他唑、法舒地尔、白蛋白、二十碳五烯酸、皮质类固醇、米诺环素和星状神经节阻滞剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploration of treatments for subarachnoid hemorrhage.

Exploration of treatments for subarachnoid hemorrhage.

Exploration of treatments for subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) continues to be a leading cause of morbidity and mortality, with cerebral vasospasm as a common etiology of worse clinical progression. The purpose of this study was to evaluate and review the current literature concerning the effective treatment of SAH. The treatment options for SAH are expanding as new therapeutic targets are identified. Nimodipine is the primary medication prescribed due to its neuroprotective properties. In addition, certain drugs can enhance lymphatic flow and influence the recovery process, such as Dexmedetomidine, SSRIs, and DL-3-n-butylphthalide. Vasospastic and ischemic patients commonly undergo transluminal balloon angioplasty. Clinical trials have not yet provided conclusive evidence to support the use of magnesium or statins. Moreover, other agents such as calcium channel blockers, milrinone, hydrogen sulfide, exosomes, erythropoietin, cilostazol, fasudil, albumin, Eicosapentaenoic acid, corticosteroids, minocycline, and stellate ganglion blockade should be investigated further.

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