离子通道研究的计算方法和理论。

IF 7.7 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY
C Guardiani, F Cecconi, L Chiodo, G Cottone, P Malgaretti, L Maragliano, M L Barabash, G Camisasca, M Ceccarelli, B Corry, R Roth, A Giacomello, B Roux
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引用次数: 0

摘要

离子通道是一种基本的生物装置,可作为确保离子在细胞膜上选择性转运的闸门;离子通道的运行构成了基本生物功能(如神经信号传输和肌肉收缩)得以实现的分子机制。在此,我们回顾了离子通道计算研究领域的最新成果,包括理论进展、最先进的模拟方法和前沿建模技术。我们还报告了连续和原子方法在表征生物和模型通道的渗透、选择性和门控机制方面的一些选定应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Computational methods and theory for ion channel research.

Computational methods and theory for ion channel research.

Ion channels are fundamental biological devices that act as gates in order to ensure selective ion transport across cellular membranes; their operation constitutes the molecular mechanism through which basic biological functions, such as nerve signal transmission and muscle contraction, are carried out. Here, we review recent results in the field of computational research on ion channels, covering theoretical advances, state-of-the-art simulation approaches, and frontline modeling techniques. We also report on few selected applications of continuum and atomistic methods to characterize the mechanisms of permeation, selectivity, and gating in biological and model channels.

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来源期刊
Advances in Physics: X
Advances in Physics: X Physics and Astronomy-General Physics and Astronomy
CiteScore
13.60
自引率
0.00%
发文量
37
审稿时长
13 weeks
期刊介绍: Advances in Physics: X is a fully open-access journal that promotes the centrality of physics and physical measurement to modern science and technology. Advances in Physics: X aims to demonstrate the interconnectivity of physics, meaning the intellectual relationships that exist between one branch of physics and another, as well as the influence of physics across (hence the “X”) traditional boundaries into other disciplines including: Chemistry Materials Science Engineering Biology Medicine
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