芝麻酚对受损周围神经的影响:功能、组织学、分子和氧化应激参数的评估。

IF 1.9 Q3 CHEMISTRY, MEDICINAL
Nastaran Amerian, Athar Talebi, Manouchehr Safari, Hamid Reza Sameni, Ali Ghanbari, Parisa Hayat, Moslem Mohammadi, Maryam Ardekanian, Sam Zarbakhsh
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引用次数: 0

摘要

目的:周围神经损伤是一种可引起感觉和运动障碍的临床问题。芝麻醇是一种抗氧化剂,可以帮助修复受损的中枢神经系统(CNS)和其他器官。本研究旨在探讨芝麻酚的抗氧化作用是否能改善大鼠受损的周围神经系统(PNS)的功能、结构和髓鞘形成。材料与方法:选用成年雄性Wistar大鼠28只,随机分为4组。假手术组将坐骨神经暴露并恢复原位,未引起挤压损伤。对照组在坐骨神经挤压损伤后腹腔注射DMSO(溶剂),试验组分别注射50或100 mg/kg芝麻酚28 d。测定坐骨神经功能指数(SFI)、超氧化物歧化酶(SOD)活性、丙二醛(MDA)水平、神经生长因子(NGF)和髓鞘蛋白零(MPZ)蛋白表达以及坐骨神经和腓肠肌的组织学指标。结果:芝麻酚能降低氧化应激参数,增加NGF和MPZ蛋白的表达,促进受损坐骨神经的功能和再生。此外,芝麻酚治疗后,腓肠肌有明显的再生。虽然两种剂量的芝麻酚都有用,但100 mg/kg的剂量比50 mg/kg的剂量更有效。结论:芝麻酚可能通过降低氧化应激,增加NGF和MPZ蛋白的表达,对大鼠周围神经损伤有改善作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters.

Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters.

Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters.

Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters.

Objective: Peripheral nerve injury is a clinical problem that may cause sensory and motor inabilities. Sesamol is an antioxidant that can help in repairing damaged central nervous system (CNS) and other organs. The present study aimed to investigate whether the antioxidant effects of sesamol could improve the function, structure, and myelination in rats' damaged peripheral nervous system (PNS).

Materials and methods: In this study, 28 adult male Wistar rats were randomly divided into four groups. In the sham group, the sciatic nerve was exposed and restored to its place without inducing crush injury. The control received DMSO (solvent) and the two experimental groups received 50 or 100 mg/kg sesamol intraperitoneally for 28 days after sciatic nerve crush injury, respectively. Next, sciatic function index (SFI), superoxide dismutase (SOD) activity, malondialdehyde (MDA) level, expression of nerve growth factor (NGF) and myelin protein zero (MPZ) proteins in the sciatic nerve, and histological indices of the sciatic nerve and gastrocnemius muscle were evaluated.

Results: The results showed that sesamol reduced oxidative stress parameters, increased expression of NGF and MPZ proteins, and improved function and regeneration of the damaged sciatic nerve. Furthermore, a significant regeneration was observed in the gastrocnemius muscle after treatment with sesamol. Although administration of both doses of sesamol was useful, the 100 mg/kg dose was more effective than the 50 mg/kg one.

Conclusion: The results suggest that sesamol may be effective in improving damaged peripheral nerves in rats by reducing oxidative stress and increasing the expression of NGF and MPZ proteins.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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