ABO血型不合肾移植后早期长期新冠肺炎肺炎：管理考虑因素和全基因组测序的作用。

IF 2.4 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephrology Pub Date : 2023-11-01 Epub Date: 2023-08-27 DOI:10.1111/nep.14235

Sara Stoler, Sebastiaan J van Hal, Steve Chadban, Thomas Le, Paul Torzillo, Rose-Marie Scarlato, Kate Wyburn, Griffith B Perkins, Tina Marinelli

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引用次数: 0

摘要

我们报告了一例近期ABO血型不合的肾移植受者持续感染严重急性呼吸系统综合征冠状病毒2型和肺炎的病例。一系列的全基因组测序证实了宿主内病毒的进化，这被用作在感染后期确认病毒活性复制和支持抗病毒药物再治疗的替代品。延长疗程的瑞德西韦联合免疫抑制调节成功清除了病毒并改善了临床。在这种情况下进行的诊断过程为其他临床医生在接近类似患者时提供了有用的指导。

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Protracted COVID-19 pneumonitis early post-ABO incompatible kidney transplantation: Management considerations and the role of whole genome sequencing.

We present the case of a recent ABO incompatible kidney transplant recipient with persistent SARS-CoV-2 infection and pneumonitis. Serial whole genome sequencing confirmed intra-host viral evolution, which was used as a surrogate to confirm active viral replication and support re-treatment with antivirals, late in the course of infection. A prolonged course of remdesivir combined with immunosuppression modulation resulted in successful clearance of virus and clinical improvement. The diagnostic process undertaken in this case provides a useful guide for other clinicians when approaching similar patients.

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来源期刊

Nephrology 医学-泌尿学与肾脏学

CiteScore

4.50

自引率

4.00%

发文量

128

审稿时长

4-8 weeks

期刊介绍： Nephrology is published eight times per year by the Asian Pacific Society of Nephrology. It has a special emphasis on the needs of Clinical Nephrologists and those in developing countries. The journal publishes reviews and papers of international interest describing original research concerned with clinical and experimental aspects of nephrology.