代谢状态调节脉络膜厚度——糖尿病眼并发症的可能早期指标?

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-12-01 DOI:10.1055/a-1831-0265

Svenja Meyhöfer, Britta Wilms, Rodrigo Chamorro, Armin Knaak, Eleni Pappa, Agnetha S Schulz, Anna-Josephin Pagels, Maria Schröder, Neele Kaluzny, Hans-Jürgen Grein, Sebastian M Meyhöfer

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引用次数: 0

摘要

目的:探讨代谢状态对健康人、肥胖患者和2型糖尿病患者脉络膜厚度(ChT)的影响。设计和方法:通过光学相干断层扫描测量空腹血糖、胰岛素、胰岛素样生长因子-1 (IGF-1)和ChT，评估健康正常体重者(n=17)、肥胖参与者(n=20)和肥胖伴T2D参与者(n=16)。结果:与健康体重正常的参与者相比，肥胖参与者和肥胖参与者合并T2D的ChT增加(P2=0.209;P = 0.002;β =0.388)和模型评估-估计胰岛素抵抗(HOMA-IR;R2 = 0.074;P = 0.015;β =0.305)是ChT的自变量，解释了其方差的20.9%和7.4%(均为p0.975)。结论:ChT与代谢特征有关。BMI和HOMA-IR。由于脉络膜功能在视网膜生理学中的关键作用，未来的研究需要评估代谢特征、ChT和潜在的代谢性眼部并发症是否存在机制联系。

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Metabolic Status Modulates Choroidal Thickness - A Possible Early Indicator for Diabetic Eye Complications?

Objective: To investigate the impact of metabolic status on choroidal thickness (ChT) in healthy subjects, patients with obesity, and type 2 diabetes.

Design and methods: Fasting blood glucose, insulin, insulin-like growth factor-1 (IGF-1), and ChT measured by optical coherence tomography were assessed in healthy normal-weight (n=17), obese participants (n=20), and obese participants with T2D (n=16).

Results: ChT increased in obese participants and obese participants with T2D as compared to healthy normal-weight participants (P<0.0001). A negative correlation was observed between IGF1 and ChT (r=-0.268, P=0.050) for all cohorts. Furthermore, body mass index (BMI; R²=0.209; P=0.002; beta=0.388) and model assessment-estimated insulin resistance (HOMA-IR; R²=0.074; P=0.015; beta=0.305) were independent variables of ChT, explaining 20.9 and 7.4% of its variance (both p<0.016), whereas age, sex, and IGF-1 were not significant confounders of ChT (p>0.975).

Conclusion: ChT is associated with metabolic characteristics, i. e., BMI and HOMA-IR. Due to the key role of choroidal function in retinal physiology, future studies are needed to evaluate whether metabolic traits, ChT, and potential metabolic eye complications are mechanistically linked.

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来源期刊

Experimental and Clinical Endocrinology & Diabetes 医学-内分泌学与代谢

CiteScore

4.10

自引率

5.60%

发文量

审稿时长

3 months

期刊介绍： Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!