宿主多态性与 COVID-19 感染。

2区医学 Q1 Chemistry

Advances in Clinical Chemistry Pub Date : 2022-01-01 Epub Date: 2021-08-23 DOI:10.1016/bs.acc.2021.07.002

Joris R Delanghe, Marijn M Speeckaert

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引用次数: 0

摘要

冠状病毒病（COVID-19）是一种由新发现的冠状病毒--严重急性呼吸系统综合征冠状病毒-2（SARS-CoV-2）引起的传染病。越来越多的证据表明，宿主遗传在 COVID-19 的严重程度中起着重要作用。根据目前对 SARS-CoV-2 进入人体的蛋白质机制、宿主先天性免疫反应和病毒与宿主相互作用的了解，人类基因多态性的潜在影响可能会导致 SARS-CoV-2 发病机制的临床差异，这可能有助于确定 COVID-19 感染的个体风险和结果。

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Host polymorphisms and COVID-19 infection.

Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). There is growing evidence that host genetics play an important role in COVID-19 severity. Based on current knowledge about the human protein machinery for SARS-CoV-2 entry, the host innate immune response, and virus-host interactions, the potential effects of human genetic polymorphisms, which may contribute to clinical differences in SARS-CoV-2 pathogenesis, may help to determine the individual risk for COVID-19 infection and outcome.

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来源期刊

Advances in Clinical Chemistry 医学-医学实验技术

CiteScore

10.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Clinical Chemistry volumes contain material by leading experts in academia and clinical laboratory science. The reviews cover a wide variety of clinical chemistry disciplines including clinical biomarker exploration, cutting edge microarray technology, proteomics and genomics. It is an indispensable resource and practical guide for practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general.