小剂量秋水仙碱治疗心包炎急性毒性的胃肠道组织病理学观察。

Q3 Medicine

International Journal of Critical Illness and Injury Science Pub Date : 2022-07-01 DOI:10.4103/ijciis.ijciis_105_21

Lisa Liu, Steven Tessier, Rodrigo Duarte-Chavez, Daniel Marino, Anish Kaza, Santo Longo, Sudip Nanda

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引用次数: 0

摘要

秋水仙碱是一种具有抗微管活性的抗炎生物碱药物。秋水仙碱毒性是一种严重且可能致命的并发症，与胃肠道等增生性组织中最明显的标志性组织病理学特征相关。这些特征仅在高剂量治疗的患者中有报道。我们报告一位患者在接受最低剂量秋水仙碱治疗后出现急性秋水仙碱毒性并伴有胃肠道组织学改变。在使用秋水仙碱时，即使是最低剂量，也必须了解药物与药物之间的相互作用以及与秋水仙碱代谢有关的器官。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Gastrointestinal histopathology of acute colchicine toxicity after lower dose treatment of pericarditis: A case report.

查看原文本刊更多论文

Gastrointestinal histopathology of acute colchicine toxicity after lower dose treatment of pericarditis: A case report.

Colchicine is an anti-inflammatory alkaloid drug with anti-microtubule activity. Colchicine toxicity is a serious and potentially fatal complication associated with hallmark histopathological features most conspicuous in proliferative tissues such as the gastrointestinal tract. These features have only been reported in patients treated with high doses. We report a patient who experienced acute colchicine toxicity with gastrointestinal histologic changes after treatment with the lowest dose of colchicine. Knowledge of drug-drug interactions and the organs involved in colchicine metabolism is imperative when using colchicine, even when administered at its lowest dose.

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来源期刊

International Journal of Critical Illness and Injury Science Medicine-Emergency Medicine

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： IJCIIS encourages research, education and dissemination of knowledge in the field of Critical Illness and Injury Science across the world thus promoting translational research by striking a synergy between basic science, clinical medicine and public health. The Journal intends to bring together scientists and academicians in the emergency intensive care and promote translational synergy between Laboratory Science, Clinical Medicine and Public Health. The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis, Data Protocols, Case Reports, Clinical Photographs, review articles and special commentaries. Students, Residents, Academicians, Public Health experts and scientists are all encouraged to be a part of this initiative by contributing, reviewing and promoting scientific works and science.