抗细菌感染的毒力治疗策略:最新进展。

IF 1.7 Q3 INFECTIOUS DISEASES
GERMS Pub Date : 2022-06-01 DOI:10.18683/germs.2022.1328
Razieh Dehbanipour, Zohreh Ghalavand
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引用次数: 16

摘要

耐多药病原体的出现和日益流行已成为一个主要的全球卫生保健问题。据世界卫生组织称,如果这种趋势继续下去,2050年感染的死亡率将高于癌症。微生物对不同种类的抗生素具有不同的耐药机制,这强调了发现新的抗微生物化合物来治疗细菌感染的必要性。通过阻断细菌的毒力因子或致病性进行抗毒治疗是一种有趣的新方法。因此,使用这些新的病原体阻滞剂可以减少广谱抗菌素的使用和耐药菌株的流行。本综述概述了2017年至2021年间发表的抗毒策略研究。大多数抗毒策略集中在粘附素、毒素和细菌通讯上。此外,在一些研究中也检测了靶向双组分系统和ncRNA元件。这些新策略有可能取代传统的抗微生物药物,并可通过靶向毒力因子用于治疗感染,特别是由耐药病原体引起的感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Anti-virulence therapeutic strategies against bacterial infections: recent advances.

Anti-virulence therapeutic strategies against bacterial infections: recent advances.

The emergence and increasing prevalence of multidrug-resistant pathogens has become a major global healthcare problem. According to the World Health Organization if these trends continue, mortality from infection in 2050 will be higher than that from cancer. Microorganisms have various resistance mechanisms against different classes of antibiotics that emphasize the need for discovery of new antimicrobial compounds to treat bacterial infections. An interesting and new strategy for disarming pathogens is antivirulence therapy by blocking bacterial virulence factors or pathogenicity. Therefore, the use of these new pathoblockers could reduce the administration of broad-spectrum antimicrobials and prevalence of resistant strains. This review provides an overview of the antivirulence strategies published studies between years 2017 and 2021. Most antivirulence strategies focused on adhesins, toxins and bacterial communication. Additionally, targeting two-component systems and ncRNA elements were also examined in some studies. These new strategies have the potential to replace traditional antimicrobial agents and can be used to treat infections, especially infections caused by resistant pathogens, by targeting virulence factors.

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来源期刊
GERMS
GERMS INFECTIOUS DISEASES-
CiteScore
2.80
自引率
5.00%
发文量
36
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