Covid-19危重疾病的恢复:ISARIC4C CCP-UK队列研究和RECOVER试验的二次分析

IF 2.1 Q3 CRITICAL CARE MEDICINE

Journal of the Intensive Care Society Pub Date : 2023-05-01 DOI:10.1177/17511437211052226

Ellen Pauley, Thomas M Drake, David M Griffith, Louise Sigfrid, Nazir I Lone, Ewen M Harrison, J Kenneth Baillie, Janet T Scott, Timothy S Walsh, Malcolm G Semple, Annemarie B Docherty

{"title":"Covid-19危重疾病的恢复:ISARIC4C CCP-UK队列研究和RECOVER试验的二次分析","authors":"Ellen Pauley, Thomas M Drake, David M Griffith, Louise Sigfrid, Nazir I Lone, Ewen M Harrison, J Kenneth Baillie, Janet T Scott, Timothy S Walsh, Malcolm G Semple, Annemarie B Docherty","doi":"10.1177/17511437211052226","DOIUrl":null,"url":null,"abstract":"Background: We aimed to compare the prevalence and severity of fatigue in survivors of Covid-19 versus non-Covid-19 critical illness, and to explore potential associations between baseline characteristics and worse recovery.Methods: We conducted a secondary analysis of two prospectively collected datasets. The population included was 92 patients who received invasive mechanical ventilation (IMV) with Covid-19, and 240 patients who received IMV with non-Covid-19 illness before the pandemic. Follow-up data were collected post-hospital discharge using self-reported questionnaires. The main outcome measures were self-reported fatigue severity and the prevalence of severe fatigue (severity >7/10) 3 and 12-months post-hospital discharge.Results: Covid-19 IMV-patients were significantly younger with less prior comorbidity, and more males, than pre-pandemic IMV-patients. At 3-months, the prevalence (38.9% [7/18] vs. 27.1% [51/188]) and severity (median 5.5/10 vs 5.0/10) of fatigue were similar between the Covid-19 and pre-pandemic populations, respectively. At 6-months, the prevalence (10.3% [3/29] vs. 32.5% [54/166]) and severity (median 2.0/10 vs. 5.7/10) of fatigue were less in the Covid-19 cohort. In the total sample of IMV-patients included (i.e. all Covid-19 and pre-pandemic patients), having Covid-19 was significantly associated with less severe fatigue (severity <7/10) after adjusting for age, sex and prior comorbidity (adjusted OR 0.35 (95%CI 0.15-0.76, p=0.01).Conclusion: Fatigue may be less severe after Covid-19 than after other critical illness.","PeriodicalId":39161,"journal":{"name":"Journal of the Intensive Care Society","volume":"24 2","pages":"162-169"},"PeriodicalIF":2.1000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225805/pdf/10.1177_17511437211052226.pdf","citationCount":"5","resultStr":"{\"title\":\"Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial.\",\"authors\":\"Ellen Pauley, Thomas M Drake, David M Griffith, Louise Sigfrid, Nazir I Lone, Ewen M Harrison, J Kenneth Baillie, Janet T Scott, Timothy S Walsh, Malcolm G Semple, Annemarie B Docherty\",\"doi\":\"10.1177/17511437211052226\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: We aimed to compare the prevalence and severity of fatigue in survivors of Covid-19 versus non-Covid-19 critical illness, and to explore potential associations between baseline characteristics and worse recovery.Methods: We conducted a secondary analysis of two prospectively collected datasets. The population included was 92 patients who received invasive mechanical ventilation (IMV) with Covid-19, and 240 patients who received IMV with non-Covid-19 illness before the pandemic. Follow-up data were collected post-hospital discharge using self-reported questionnaires. The main outcome measures were self-reported fatigue severity and the prevalence of severe fatigue (severity >7/10) 3 and 12-months post-hospital discharge.Results: Covid-19 IMV-patients were significantly younger with less prior comorbidity, and more males, than pre-pandemic IMV-patients. At 3-months, the prevalence (38.9% [7/18] vs. 27.1% [51/188]) and severity (median 5.5/10 vs 5.0/10) of fatigue were similar between the Covid-19 and pre-pandemic populations, respectively. At 6-months, the prevalence (10.3% [3/29] vs. 32.5% [54/166]) and severity (median 2.0/10 vs. 5.7/10) of fatigue were less in the Covid-19 cohort. In the total sample of IMV-patients included (i.e. all Covid-19 and pre-pandemic patients), having Covid-19 was significantly associated with less severe fatigue (severity <7/10) after adjusting for age, sex and prior comorbidity (adjusted OR 0.35 (95%CI 0.15-0.76, p=0.01).Conclusion: Fatigue may be less severe after Covid-19 than after other critical illness.\",\"PeriodicalId\":39161,\"journal\":{\"name\":\"Journal of the Intensive Care Society\",\"volume\":\"24 2\",\"pages\":\"162-169\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225805/pdf/10.1177_17511437211052226.pdf\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Intensive Care Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/17511437211052226\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CRITICAL CARE MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Intensive Care Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/17511437211052226","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}

引用次数: 5

摘要

背景:我们旨在比较Covid-19与非Covid-19危重疾病幸存者的疲劳患病率和严重程度，并探讨基线特征与较差恢复之间的潜在关联。方法:我们对两个前瞻性收集的数据集进行了二次分析。纳入的人群包括92名接受有创机械通气(IMV)治疗的Covid-19患者，以及240名在大流行前接受有创机械通气(IMV)治疗的非Covid-19疾病患者。出院后随访数据采用自我报告问卷收集。主要结局指标是自我报告的疲劳严重程度和出院后3个月和12个月的严重疲劳患病率(严重程度>7/10)。结果:与大流行前的imv患者相比，Covid-19 imv患者明显更年轻，既往合并症更少，男性更多。3个月时，新冠肺炎和大流行前人群的疲劳患病率(38.9% [7/18]vs 27.1%[51/188])和严重程度(中位数5.5/10 vs 5.0/10)相似。6个月时，新冠肺炎队列的疲劳患病率(10.3%[3/29]对32.5%[54/166])和严重程度(中位数2.0/10对5.7/10)较低。在纳入的imv患者总样本中(即所有Covid-19和大流行前患者)，感染Covid-19与较轻的疲劳程度显著相关(严重程度p=0.01)。结论:新冠肺炎患者的疲劳程度可能低于其他危重疾病患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial.

Background: We aimed to compare the prevalence and severity of fatigue in survivors of Covid-19 versus non-Covid-19 critical illness, and to explore potential associations between baseline characteristics and worse recovery.

Methods: We conducted a secondary analysis of two prospectively collected datasets. The population included was 92 patients who received invasive mechanical ventilation (IMV) with Covid-19, and 240 patients who received IMV with non-Covid-19 illness before the pandemic. Follow-up data were collected post-hospital discharge using self-reported questionnaires. The main outcome measures were self-reported fatigue severity and the prevalence of severe fatigue (severity >7/10) 3 and 12-months post-hospital discharge.

Results: Covid-19 IMV-patients were significantly younger with less prior comorbidity, and more males, than pre-pandemic IMV-patients. At 3-months, the prevalence (38.9% [7/18] vs. 27.1% [51/188]) and severity (median 5.5/10 vs 5.0/10) of fatigue were similar between the Covid-19 and pre-pandemic populations, respectively. At 6-months, the prevalence (10.3% [3/29] vs. 32.5% [54/166]) and severity (median 2.0/10 vs. 5.7/10) of fatigue were less in the Covid-19 cohort. In the total sample of IMV-patients included (i.e. all Covid-19 and pre-pandemic patients), having Covid-19 was significantly associated with less severe fatigue (severity <7/10) after adjusting for age, sex and prior comorbidity (adjusted OR 0.35 (95%CI 0.15-0.76, p=0.01).

Conclusion: Fatigue may be less severe after Covid-19 than after other critical illness.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of the Intensive Care Society Nursing-Critical Care Nursing

CiteScore

4.40

自引率

0.00%

发文量

期刊介绍： The Journal of the Intensive Care Society (JICS) is an international, peer-reviewed journal that strives to disseminate clinically and scientifically relevant peer-reviewed research, evaluation, experience and opinion to all staff working in the field of intensive care medicine. Our aim is to inform clinicians on the provision of best practice and provide direction for innovative scientific research in what is one of the broadest and most multi-disciplinary healthcare specialties. While original articles and systematic reviews lie at the heart of the Journal, we also value and recognise the need for opinion articles, case reports and correspondence to guide clinically and scientifically important areas in which conclusive evidence is lacking. The style of the Journal is based on its founding mission statement to ‘instruct, inform and entertain by encompassing the best aspects of both tabloid and broadsheet''.