Tenofovir y enfermedad ósea en pacientes infectados por el VIH

As a result of the introduction of high activity antiretroviral therapy (HAART), the situation of human immunodeficiency virus (HIV) infected patients has changed radically in developed countries. Both their survival and quality of life have improved. It is now when the long-term consequences, such as osteoporosis, of HIV infection are being communicated. There are many communications that refer to the greater prevalence of osteopenia and osteoporosis among these patients. Consequently, an increase in the number of osteoporotic fractures is to be expected. Among the mechanisms responsible for the loss of bone mass are the effect of HIV infection and antiretroviral therapy, this being a controversial subject of discussion that requires a greater number of studies. Herein, we review the osteoporosis in the HIV population, focusing on the risk factors and studies that involve antiretroviral treatment as an etiological agent and, fundamentally, tenofovir.