肾上腺皮质癌药物治疗的现状展望。

IF 2.5 4区 医学 Q3 ONCOLOGY
Hanna Ławnicka
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引用次数: 3

摘要

肾上腺皮质癌(ACC)是一种罕见但侵袭性很强的内分泌系统恶性肿瘤,具有特殊的生物学特征,通常以激素活性和高侵袭性为特征,在最初诊断时通常导致局部侵袭或转移性疾病。尽管对新策略进行了激烈的多向搜索,但目前临床上使用的标准治疗方法的有效性并没有令人满意的改善。ACC诊断通常意味着预后不良。因此,在临床管理中识别和实施新的更有效的ACC治疗方法的必要性仍然是一个雄心勃勃的挑战。本文简要总结了目前肾上腺皮质癌的治疗现状,重点介绍了ACC药物治疗的新前景,包括靶向治疗、免疫治疗和检查点抑制剂、治疗学,最后,基于准确识别ACC细胞特定遗传谱的个性化分子方法,利用下一代测序方法作为精确个性化治疗的新视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current Prospects for Adrenocortical Carcinoma Pharmacotherapy.

Adrenocortical carcinoma (ACC) is a rare but very aggressive malignancy of the endocrine system with specific biology characterized frequently by hormonal activity and high aggressiveness, resulting usually in locally-invasive or metastatic disease at the time of initial diagnosis. Despite an intense multidirectional search for novel strategies, there has been no satisfactory improvement in the effectiveness of standard therapy currently used in the clinic. ACC diagnosis usually means poor prognosis. Thus, the necessity to identify and implement novel and more effective treatment of ACC in clinical management remains constantly an ambitious challenge. The review briefly summarizes the current management of adrenocortical carcinoma and focuses mainly on novel prospects for ACC pharmacotherapy, including targeted therapies, immunotherapy and checkpoint inhibitors, theranostics, and at last, the individualized molecular approach based on the exact identification of specific genetic profile of ACC cells using next-generation sequencing methods as the next-generation perspective for precisely personalized therapy.

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来源期刊
CiteScore
4.50
自引率
7.10%
发文量
55
审稿时长
3 months
期刊介绍: Aims & Scope Recent Patents on Anti-Cancer Drug Discovery publishes review and research articles that reflect or deal with studies in relation to a patent, application of reported patents in a study, discussion of comparison of results regarding application of a given patent, etc., and also guest edited thematic issues on recent patents in the field of anti-cancer drug discovery e.g. on novel bioactive compounds, analogs, targets & predictive biomarkers & drug efficacy biomarkers. The journal also publishes book reviews of eBooks and books on anti-cancer drug discovery. A selection of important and recent patents on anti-cancer drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-cancer drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-cancer drug discovery.
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