肿瘤细胞与肿瘤相关巨噬细胞间脂质代谢调节串扰。

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shu Liu, Ying Ying Shen, Li Yang Yin, Jianghua Liu, Xuyu Zu
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引用次数: 0

摘要

在肿瘤微环境中,肿瘤相关巨噬细胞(tumor-associated macrophages, tam)是最丰富的细胞群之一,在肿瘤发生、化疗耐药、免疫逃避和转移中起着关键作用。tam与癌细胞之间存在重要的相互作用:一方面,肿瘤控制浸润性巨噬细胞的功能,促进tam的重编程,另一方面,tam影响癌细胞的生长。本文就肿瘤细胞与tam之间复杂关系中的脂质代谢变化作一综述。我们讨论了癌细胞中的脂质代谢如何影响巨噬细胞表型和代谢变化,以及随后,tam的脂质代谢改变如何影响肿瘤进展。确定影响肿瘤细胞与tam之间复杂相互作用的代谢变化也是探索新的治疗方法的重要一步,这些治疗方法以免疫细胞的代谢重编程为目标,增强其杀瘤潜能和旁路治疗耐药性。我们的工作可能为抗肿瘤治疗提供新的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipid Metabolic Regulatory Crosstalk Between Cancer Cells and Tumor-Associated Macrophages.

In the tumor microenvironment, tumor-associated macrophages (TAMs) are one of the most abundant cell populations, playing key roles in tumorigenesis, chemoresistance, immune evasion, and metastasis. There is an important interaction between TAMs and cancer cells: on the one hand, tumors control the function of infiltrating macrophages, contributing to reprogramming of TAMs, and on the other hand, TAMs affect the growth of cancer cells. This review focuses on lipid metabolism changes in the complex relationship between cancer cells and TAMs. We discuss how lipid metabolism in cancer cells affects macrophage phenotypic and metabolic changes and, subsequently, how altered lipid metabolism of TAMs influences tumor progression. Identifying the metabolic changes that influence the complex interaction between tumor cells and TAMs is also an important step in exploring new therapeutic approaches that target metabolic reprogramming of immune cells to enhance their tumoricidal potential and bypass therapy resistance. Our work may provide new targets for antitumor therapies.

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来源期刊
DNA and cell biology
DNA and cell biology 生物-生化与分子生物学
CiteScore
6.60
自引率
0.00%
发文量
93
审稿时长
1.5 months
期刊介绍: DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.
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