一位八十多岁老人鼻咽和肛门拭子中SARS-CoV-2可能的个体演化:一份病例报告

IF 1.7 Q3 INFECTIOUS DISEASES
GERMS Pub Date : 2022-06-01 DOI:10.18683/germs.2022.1332
Jamal Zaini, Andika Chandra Putra, Asep Muhamad Ridwanuloh, Zahrah Saniyyah, Budi Haryanto, Ahmad Rusdan Handoyo Utomo, Anik Budhi Dharmayanthi, Anggia Prasetyoputri, Ade Andriani, Hariyatun Hariyatun, Isa Nuryana, Syam Budi Iryanto, Sugiyono Saputra, Andri Wardiana, Ratih Asmana Ningrum
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引用次数: 0

摘要

简介:COVID-19是一种新发传染病,有待进一步研究。病例报告:在这里,我们描述了一位患有合并症的80多岁女性的COVID-19病例,她在住院期间缓慢恢复,但在住院2周后因心源性猝死而死亡。在住院第7天,她的鼻咽和肛门拭子经RT-PCR检测为SARS-CoV-2阳性。NGS显示病毒可能在个体内进化。鼻咽拭子样本产生B.1470变异,分类为GH进化支。该变异在穗基因D614G上发生突变;N基因;NS3基因;NSP2基因和NSP12基因。肛拭子样本显示类似突变,但在刺突基因S12F上增加了点突变,分类为B.1.465变异。结论:还应考虑胃肠道作为病毒突变蓄积库的可能性,并进一步研究环境中病毒粪便传播的潜在影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Possible intraindividual evolution of SARS-CoV-2 in nasopharyngeal and anal swab in an octogenarian: a case report.

Introduction: COVID-19 is an emerging infectious disease that remains to be further investigated.

Case report: Here, we describe a case of COVID-19 in an octogenarian woman with comorbidities who slowly recovered during hospitalization, but died due to sudden cardiac death after 2 weeks of hospitalization. Her nasopharyngeal and anal swabs returned positive for SARS-CoV-2 by RT-PCR on day 7 of hospitalization. The NGS showed possible intraindividual evolution of virus. The sample from the nasopharyngeal swab yielded a B.1470 variant classified as clade GH. This variant showed mutation in the spike gene D614G; N gene; NS3 gene; NSP2 gene and NSP12 gene. The sample from the anal swab showed similar mutation but with additional point mutation in spike gene S12F and was classified as B.1.465 variant.

Conclusions: The possibility of the gastrointestinal tract that served as reservoir for virus mutation accumulation should also be considered and the potential impact of viral fecal transmission in the environment should be further investigated.

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来源期刊
GERMS
GERMS INFECTIOUS DISEASES-
CiteScore
2.80
自引率
5.00%
发文量
36
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