拉莫三嗪诱导的Stevens-Johnson综合征/中毒性表皮坏死松解的遗传易感因素:一项系统回顾和荟萃分析。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-01 DOI:10.2217/pme-2022-0126

Sayan Kumar Das, Ananyan Sampath, Sameer Uz Zaman, Ayan Kumar Pati, Shubham Atal

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引用次数: 0

摘要

研究报告了HLA等位基因的表达与拉莫三嗪(LTG)诱导的史蒂文斯-约翰逊综合征(SJS)之间的关联。本系统综述和荟萃分析评估了HLA等位基因与不同人群中ltg诱导的SJS之间的关系。HLA-B*0702和HLA-C*0702两个等位基因被认为具有保护作用;HLA-B*1502、HLA-B*4403、HLA-A*2402、CYP2C19*2和HLA-B*38这5个等位基因可能在ltg诱导的SJS中发挥作用，目前只能提取HLA-B*1502的相关数据。合并优势比为2.88,95% CI为1.60-5.17,p值为0.0004，确定HLA-B*1502是ltg诱导的SJS/中毒性表皮坏死松解(TEN)发生的主要危险因素。虽然已经确定了多个可能在ltg诱导的SJS/TEN发展中起作用的等位基因，但风险等位基因的表达可能是遗传特异性的，为了预防这种危及生命的药物不良反应，有必要进行遗传筛查。

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Genetic predisposition for the development of lamotrigine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis.

Studies report an association between the expression of HLA alleles and lamotrigine (LTG)-induced Stevens-Johnson syndrome (SJS). This systematic review and meta-analysis evaluates the association between HLA alleles and LTG-induced SJS in different populations. Two alleles, HLA-B*0702 and HLA-C*0702, were deemed to be protective; five alleles, HLA-B*1502, HLA-B*4403, HLA-A*2402, CYP2C19*2 and HLA-B*38, may play a role in LTG-induced SJS, for which only data studying HLA-B*1502 could be extracted. The pooled odds ratio of 2.88, 95% CI of 1.60-5.17 and p-value of 0.0004 establish the presence of HLA-B*1502 as a major risk factor for the development of LTG-induced SJS/toxic epidermal necrolysis (TEN). Although multiple alleles that may play a role in the development of LTG-induced SJS/TEN were identified, the expression of the risk alleles may be ancestry-specific, and genetic screening is warranted for preventing this life-threatening adverse drug reaction.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.