moojeni Bothrops毒液及其成分综述。

Journal of Venom Research Pub Date : 2021-01-01
Fernanda D'Amélio, Hugo Vigerelli, Álvaro Rossan de Brandão Prieto da Silva, Irina Kerkis
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引用次数: 0

摘要

Bothrops moojeni属毒蛇科,广泛分布于南美洲、阿根廷、玻利维亚、巴西和巴拉圭的热带稀树草原生态地区(塞拉多),在巴西具有重要的医学意义。该物种引起的意外事故随着组织炎症的发展具有快速的局部作用,引起红斑、疼痛和凝血时间增加,最终可导致坏疽或组织坏死。Bothrops moojeni毒液具有丰富的成分,但尚未得到充分的研究,这对于阐明毒液的毒性过程和大量新的生物活性分子都是至关重要的。本文旨在分析该毒液的结构和生物学特性,并强调该毒液的药理和生物技术潜力。尽管几代人都在研究蛇毒的毒性作用,但创新研究将其成分作为发现具有药理和生物技术潜力的新治疗靶点和新分子的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

<i>Bothrops moojeni</i> venom and its components - an overview.

<i>Bothrops moojeni</i> venom and its components - an overview.

Bothrops moojeni venom and its components - an overview.

Belonging to the Viperidae family, Bothrops moojeni are widely distributed in South America, tropical savanna ecoregion (Cerrado) of Argentina, Bolivia, Brazil, and Paraguay with medical importance in Brazil. Accidents caused by this species have a rapid local action with the development of tissue inflammation, causing erythema, pain, and increased clotting time, which can culminate in gangrene or tissue necrosis. Bothrops moojeni venom has a rich composition that remains underexplored, which is of utmost importance, both for elucidating the envenoming process and the vast library of new bioactive molecules kind of venom can offer. This review aims to analyze which components of the venom have already been characterized towards its structure and biological effect and highlight the pharmacological and biotechnological potential of this venom. Although snake venoms have been studied for their toxic effects for generations, innovative studies address their components as tools for discovering new therapeutic targets and new molecules with pharmacological and biotechnological potential.

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