乙型肝炎病毒相关肝细胞癌的初步放射基因组学研究:MRI特征与突变之间的关系

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-01 DOI:10.2217/pme-2022-0093

Shanshan Gao, Feihang Wang, Wei Sun, Xianling Qian, Yuan Ji, Yunfeng Cheng, Xiaolin Wang, Lingxiao Liu, Ruofan Sheng, Mengsu Zeng

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引用次数: 0

摘要

目的:探讨乙型肝炎病毒(HBV)相关肝细胞癌(HCC)的MRI特征与高频突变之间的关系。方法:本研究纳入了58例HCC患者，他们在手术切除前进行了对比增强MRI检查并进行了基因组测序。评估MRI特征和突变信息。结果:HCC中前5位突变基因分别为TP53(53.45%)、TAF1(24.14%)、PDE4DIP(22.41%)、ABCA13(18.97%)和LRP1B(17.24%)。TP53和LRP1B突变分别与肿瘤坏死(p = 0.035)和镶嵌结构(p = 0.015)相关。ABCA13突变与马赛克结构(p = 0.025)和坏死(p = 0.010)相关。结论:这项初步的放射基因组学分析显示，MRI特征与hbv相关hcc的高频突变之间存在关联。

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Preliminary radiogenomic study of hepatitis B virus-related hepatocellular carcinoma: associations between MRI features and mutations.

Aim: To investigate associations between MRI features and high-frequency mutations of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods: This study included 58 HCC patients who underwent contrast-enhanced MRI prior to surgical resection and genome sequencing. MRI features and mutation information were evaluated. Results: The top five most frequently mutated genes in HCC were TP53 (53.45%), TAF1 (24.14%), PDE4DIP (22.41%), ABCA13 (18.97%) and LRP1B (17.24%). Mutations in TP53 and LRP1B were associated with tumor necrosis (p = 0.035) and mosaic architecture (p = 0.015), respectively. Mutations in ABCA13 were associated with mosaic architecture (p = 0.025) and necrosis (p = 0.010). Conclusion: This preliminary radiogenomics analysis showed associations between MRI features and high-frequency mutations in HBV-related HCCs.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.