{"title":"生命的起源:首先是进化动力学。","authors":"Charles Kocher, Ken A Dill","doi":"10.1017/qrd.2023.2","DOIUrl":null,"url":null,"abstract":"<p><p>When life arose from prebiotic molecules 3.5 billion years ago, what came first? Informational molecules (RNA, DNA), functional ones (proteins), or something else? We argue here for a different logic: rather than seeking a <i>molecule type</i>, we seek a <i>dynamical process.</i> Biology required an ability to evolve before it could choose and optimise materials. We hypothesise that the <i>evolution process</i> was rooted in the <i>peptide folding process.</i> Modelling shows how short random peptides can collapse in water and catalyse the elongation of others, powering both increased folding stability and emergent autocatalysis through a disorder-to-order process.</p>","PeriodicalId":34636,"journal":{"name":"QRB Discovery","volume":"4 ","pages":"e4"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392681/pdf/","citationCount":"1","resultStr":"{\"title\":\"Origins of life: first came evolutionary dynamics.\",\"authors\":\"Charles Kocher, Ken A Dill\",\"doi\":\"10.1017/qrd.2023.2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>When life arose from prebiotic molecules 3.5 billion years ago, what came first? Informational molecules (RNA, DNA), functional ones (proteins), or something else? We argue here for a different logic: rather than seeking a <i>molecule type</i>, we seek a <i>dynamical process.</i> Biology required an ability to evolve before it could choose and optimise materials. We hypothesise that the <i>evolution process</i> was rooted in the <i>peptide folding process.</i> Modelling shows how short random peptides can collapse in water and catalyse the elongation of others, powering both increased folding stability and emergent autocatalysis through a disorder-to-order process.</p>\",\"PeriodicalId\":34636,\"journal\":{\"name\":\"QRB Discovery\",\"volume\":\"4 \",\"pages\":\"e4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392681/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"QRB Discovery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1017/qrd.2023.2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"QRB Discovery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1017/qrd.2023.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Origins of life: first came evolutionary dynamics.
When life arose from prebiotic molecules 3.5 billion years ago, what came first? Informational molecules (RNA, DNA), functional ones (proteins), or something else? We argue here for a different logic: rather than seeking a molecule type, we seek a dynamical process. Biology required an ability to evolve before it could choose and optimise materials. We hypothesise that the evolution process was rooted in the peptide folding process. Modelling shows how short random peptides can collapse in water and catalyse the elongation of others, powering both increased folding stability and emergent autocatalysis through a disorder-to-order process.