比较 SARS-CoV-2 感染动物模型的心血管病理:关于研究方法标准化的建议。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Comparative medicine Pub Date : 2023-02-01 Epub Date: 2023-02-02 DOI:10.30802/AALAS-CM-22-000095
Kathleen Gabrielson, Stephanie Myers, Jena Yi, Edward Gabrielson, Isabel A Jimenez
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引用次数: 0

摘要

严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)是导致 2019 年底开始的 COVID-19 全球大流行的病毒病原体。由于 SARS-CoV-2 主要导致呼吸系统疾病,因此迄今为止开展的大部分研究都集中在呼吸系统。然而,SARS-CoV-2 感染也会影响其他器官系统,包括心血管系统。在这份对已发表数据的批判性分析中,我们评估了人类患者和动物心血管病变的证据。总体而言,我们发现在人类尸检研究和 SARS-CoV-2 感染的动物模型中,很少有关于心血管病变存在与否的报道。此外,在那些报告了心血管病变的研究中,我们发现了其设计和执行中存在的问题,这些问题降低了人们对 SARS-CoV-2 感染导致严重心血管病变的结论的信心。在本综述中,我们将进一步阐述这些局限性,并提出建议,以确保高水平的科学严谨性和可重复性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Cardiovascular Pathology In Animal Models of SARS-CoV-2 Infection: Recommendations Regarding Standardization of Research Methods.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as the viral pathogen that led to the global COVID-19 pandemic that began in late 2019. Because SARS-CoV-2 primarily causes a respiratory disease, much research conducted to date has focused on the respiratory system. However, SARS-CoV-2 infection also affects other organ systems, including the cardiovascular system. In this critical analysis of published data, we evaluate the evidence of cardiovascular pathology in human patients and animals. Overall, we find that the presence or absence of cardiovascular pathology is reported infrequently in both human autopsy studies and animal models of SARS-CoV-2 infection. Moreover, in those studies that have reported cardiovascular pathology, we identified issues in their design and execution that reduce confidence in the conclusions regarding SARS-CoV-2 infection as a cause of significant cardiovascular pathology. Throughout this overview, we expand on these limitations and provide recommendations to ensure a high level of scientific rigor and reproducibility.

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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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