血小板分布宽度作为大面积烧伤患者急性肾损伤早期预测指标的评估。

IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE
Emergency Medicine International Pub Date : 2023-09-07 eCollection Date: 2023-01-01 DOI:10.1155/2023/6694313
Ming Jiang, Qingrong Zhang, Chuwei Zhang, Zihan Li, Qiqi Li, Xun Qu, Yi Zhang, Kesu Hu
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引用次数: 0

摘要

背景:大面积烧伤破坏创伤。本研究旨在分析早期血小板(PLT)指数对严重烧伤后急性肾损伤(AKI)发展的预测价值。方法和结果:186例大面积烧伤(烧伤面积≥30%)患者最终被烧伤。多变量分析指出,前24小时的血小板分布宽度(PDW) 入院后h是严重烧伤患者AKI、严重AKI和RRT需求的独立危险因素,PDW每增加1%,AKI风险增加30.9%(OR = 1.309,CI,1.075-1.594和P = 0.007)。发现预测AKI的PDW的ROC曲线下面积(AUC)为0.735,并且在结合PDW和血尿素氮(BUN)后AKI的AUC值为0.81。基于截止值PDW = 17.7%的患者分为高危(PDW≥17.7%)和低危(PDW P  <  0.001),因为风险水平增加。结论:早期PDW水平是大面积烧伤并发AKI、严重AKI和RRT需求的重要危险因素。当PDW>17.7%时,烧伤患者不仅AKI的风险更高,而且AKI的严重程度也可能更高。由于低成本和广泛的可用性,PDW有潜力成为预测大面积烧伤患者AKI的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evaluation of Platelet Distribution Width as an Early Predictor of Acute Kidney Injury in Extensive Burn Patients.

Evaluation of Platelet Distribution Width as an Early Predictor of Acute Kidney Injury in Extensive Burn Patients.

Evaluation of Platelet Distribution Width as an Early Predictor of Acute Kidney Injury in Extensive Burn Patients.

Evaluation of Platelet Distribution Width as an Early Predictor of Acute Kidney Injury in Extensive Burn Patients.

Background: The extensive burns devastate trauma. The research was designed to analyse the predictive value of early platelet (PLT) indices on the development of acute kidney injury (AKI) after severe burns.

Methods and results: 186 patients with extensive burns (burn area ≥30%) were eventually involved. Multivariate analyses pointed out that platelet distribution width (PDW) in the first 24 h after admission was an independent risk factor for AKI, severe AKI, and RRT requirement in patients with severe burns, and AKI risk showed an increase of 30.9% per increase of 1% in PDW (OR = 1.309, CI, 1.075-1.594, and P = 0.007). It was found that the area under the ROC curve (AUC) of PDW predicting AKI was 0.735 and that the AUC value was 0.81 for AKI after combining PDW and blood urea nitrogen (BUN). Based on the cut-off value PDW = 17.7%, patients were divided into high- (PDW ≥17.7%) and low-risk (PDW <17.7%) groups. In the KM analysis, there was a higher cumulative incidence of AKI if patients were in a high-risk group (in 30 days); and the stages of AKI showed a linear upward trend (chi-square test for linear trend P  <  0.001) as there was an increase in the risk level.

Conclusion: The PDW level in the early stage serves as an important risk factor for AKI, severe AKI, and RRT requirement in extensive burns. When PDW >17.7%, burn patients are not only at a higher risk for AKI but may also have higher AKI severity. Due to low cost and wide availability, PDW has the potential to be the tool that can predict AKI in extensive burn patients.

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来源期刊
Emergency Medicine International
Emergency Medicine International EMERGENCY MEDICINE-
CiteScore
0.10
自引率
0.00%
发文量
187
审稿时长
17 weeks
期刊介绍: Emergency Medicine International is a peer-reviewed, Open Access journal that provides a forum for doctors, nurses, paramedics and ambulance staff. The journal publishes original research articles, review articles, and clinical studies related to prehospital care, disaster preparedness and response, acute medical and paediatric emergencies, critical care, sports medicine, wound care, and toxicology.
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