纳米银纳米粒子与马钱子局部治疗宫颈病变中的Coville:随机临床试验。

IF 1.2 4区医学 Q3 NURSING

Revista da Escola de Enfermagem da U S P Pub Date : 2023-01-01 DOI:10.1590/1980-220X-REEUSP-2022-0338en

Cristiane Araújo Nascimento, Ana Caroline Melo Dos Santos, Denise Macedo da Silva, Nirliane Ribeiro Barbosa, Edilson Leite de Moura, Veracilda Bezerra da Silva, Tatiane Luciano Balliano, Elaine Virginia Martins de Souza Figueiredo, Karol Fireman de Farias, Guilherme Benjamin Brandão Pitta

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引用次数: 0

摘要

目的:探讨融合技术作为治疗宫颈病变主题的新方法的可行性。方法:前瞻性随机、双盲、对照临床试验。在本研究的实施过程中，纳入了43名妇女，并将其分为临床健康且使用统一卫生系统的A组(不含银纳米颗粒的软膏n = 23)和B组(含银纳米颗粒的软膏n = 20)。结果:使用软膏前后IVA试验(p = 0.15)、Schiller试验(p = 0.15)、细胞学细胞变化(p = 0.47)、微生物学分析(p = 0.89)比较差异均无统计学意义。使用后，所研究样品未见不良反应。结论:根据本研究确定的结果，确定该产品是安全的，不会引起不良事件。关于本品对宫颈病变的疗效，有必要继续进行II期研究。巴西信息系统登记处Clínicos: UTN: U1111-1218-2820。

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Treatment topical with silver nanoparticles and Stryphnodendron Adstringens (Mart.) Coville in cervical lesions: randomized clinical trial.

Objective: To assess the feasibility of incorporating technology as a new alternative for treating topics on cervical lesions.

Method: This is a randomized, double-blind, controlled clinical trial with a prospective design. During the realization of this study, 43 women were included and divided between groups A (ointment without silver nanoparticles n = 23) and B (ointment with silver nanoparticles n = 20) clinically healthy and who used the unified health system.

Results: There were no significant differences when comparing before and after the use of ointment for IVA test (p = 0.15), Schiller test (p = 0.15), cellular changes (p = 0.47) and microbiological analysis (p = 0.89) through cytology. After use, no adverse reaction was observed in the sample studied.

Conclusion: Based on the results identified in this study, identified that the product is safe and does not promote adverse events. Regarding the effectiveness of the product in uterine cervical lesions, it is necessary to continue the study in phase II. Registro de Ensaios Clínicos Brasileiros: UTN: U1111-1218-2820.

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来源期刊

Revista da Escola de Enfermagem da U S P 医学-护理

CiteScore

1.70

自引率

11.10%

发文量

254

审稿时长

3-8 weeks

期刊介绍： The University of São Paulo Nursing School Journal (Revista da Escola de Enfermagem da USP, REEUSP) is a bimonthly periodical revised by fellow nurses, which has the objective of publishing empirical or theoretical articles that represent a significant advance for the professional practice or for the fundaments of Nursing Mission: to stimulate knowledge production and dissemination in Nursing and related areas, focusing on international interlocution to advance Nursing science. Areas of Interest: Nursing and Health Its abbreviated title is Rev Esc Enferm USP, which should be used in bibliographies, footnotes and bibliographical references and strips.