两个还不够：合成策略和非自然碱基对的应用。

IF 2.9 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Chemistry Pub Date : 2023-06-26 Print Date: 2023-09-26 DOI:10.1515/hsz-2023-0169

Robert Dörrenhaus, Philip K Wagner, Stephanie Kath-Schorr

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引用次数: 1

摘要

核酸化学是一个快速发展的领域，对用于诊断和治疗、材料科学或研究细胞过程的新型核苷酸修饰和人工核苷酸构建块的需求有增无减。这篇综述的重点是非自然碱基对作为扩展遗传字母表的一部分的发展和应用。不仅介绍了“类自然”人工碱基对的最新进展，还介绍了获得C-糖苷核苷酸的最新合成方法。合成中的宽范围生存能力是在更宽的光谱中成功使用非天然碱基对的先决条件，并将进行讨论。

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Two are not enough: synthetic strategies and applications of unnatural base pairs.

Nucleic acid chemistry is a rapidly evolving field, and the need for novel nucleotide modifications and artificial nucleotide building blocks for diagnostic and therapeutic use, material science or for studying cellular processes continues unabated. This review focusses on the development and application of unnatural base pairs as part of an expanded genetic alphabet. Not only recent developments in "nature-like" artificial base pairs are presented, but also current synthetic methods to get access to C-glycosidic nucleotides. Wide-ranging viability in synthesis is a prerequisite for the successful use of unnatural base pairs in a broader spectrum and will be discussed.

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来源期刊

Biological Chemistry 生物-生化与分子生物学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.