原因与繁殖:基因编辑与遗传选择。

IF 17 1区 哲学 Q1 ETHICS
American Journal of Bioethics Pub Date : 2024-08-01 Epub Date: 2023-09-11 DOI:10.1080/15265161.2023.2250288
Jeff McMahan, Julian Savulescu
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引用次数: 0

摘要

许多生物伦理学、科学和医学的作者认为,胚胎选择在道德上比基因编辑更能避免遗传疾病,因为基因编辑有前者没有的风险。我们认为,使用基因编辑的一个原因是,在许多情况下,这对从编辑过的胚胎中发育出来的人来说会更好,所以如果不这样做,对那个人来说会更糟。相比之下,胚胎选择对从所选胚胎发育而来的人来说从来都不是更好的。然而,使用基因编辑的理由受到了两个方面的质疑:首先,从道德上讲,无论坏效果对某人来说更糟,还是好效果对某人更好,都没有区别;其次,有益的基因编辑对从编辑过的胚胎中发育出来的人来说并不是更好的。我们认为,这两种反对意见都可以得到令人满意的回答,因此,至少在某些情况下,使用基因编辑而不是胚胎选择确实有重要的道德理由。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reasons and Reproduction: Gene Editing and Genetic Selection.

Many writers in bioethics, science, and medicine contend that embryo selection is a morally better way of avoiding genetic disorders then gene editing, as the latter has risks that the former does not. We argue that one reason to use gene editing is that in many cases it would be better for the person who would develop from the edited embryo, so that not to have done it would have been worse for that person. By contrast, embryo selection is never better for the person who develops from the selected embryo. This reason to use gene editing has, however, been challenged on two grounds: first, that it makes no difference, morally, whether a bad effect is worse for someone, or a good effect better for someone; and, second, that beneficent gene editing would not be unequivocally better for the person who would develop from the edited embryo. We argue that both of these objections can be satisfactorily answered and thus that there is indeed a significant moral reason, at least in some cases, to use gene editing rather than embryo selection.

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来源期刊
American Journal of Bioethics
American Journal of Bioethics 社会科学-科学史与科学哲学
CiteScore
12.30
自引率
26.90%
发文量
250
审稿时长
6-12 weeks
期刊介绍: The American Journal of Bioethics (AJOB) is a renowned global publication focused on bioethics. It tackles pressing ethical challenges in the realm of health sciences. With a commitment to the original vision of bioethics, AJOB explores the social consequences of advancements in biomedicine. It sparks meaningful discussions that have proved invaluable to a wide range of professionals, including judges, senators, journalists, scholars, and educators. AJOB covers various areas of interest, such as the ethical implications of clinical research, ensuring access to healthcare services, and the responsible handling of medical records and data. The journal welcomes contributions in the form of target articles presenting original research, open peer commentaries facilitating a dialogue, book reviews, and responses to open peer commentaries. By presenting insightful and authoritative content, AJOB continues to shape the field of bioethics and engage diverse stakeholders in crucial conversations about the intersection of medicine, ethics, and society.
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