内溶酶体双孔通道及其蛋白伙伴。

Q1 Pharmacology, Toxicology and Pharmaceutics

Handbook of experimental pharmacology Pub Date : 2023-01-01 DOI:10.1007/164_2022_601

Sandip Patel, Spyros Zissimopoulos, Jonathan S Marchant

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引用次数: 0

摘要

双孔通道是在酸性细胞器上表达的离子通道，如构成内溶酶体系统的各种囊泡。它们可以渗透到Ca2+和Na+中，并被第二信使NAADP以及磷酸肌苷、PI(3,5)P2和/或电压激活。在这里，我们回顾了与这些通道相互作用的蛋白质，包括最近发现的NAADP受体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Endo-Lysosomal Two-Pore Channels and Their Protein Partners.

Two-pore channels are ion channels expressed on acidic organelles such as the various vesicles that constitute the endo-lysosomal system. They are permeable to Ca²⁺ and Na⁺ and activated by the second messenger NAADP as well as the phosphoinositide, PI(3,5)P₂ and/or voltage. Here, we review the proteins that interact with these channels including recently identified NAADP receptors.

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来源期刊

Handbook of experimental pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.20

自引率

0.00%

发文量

期刊介绍： The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and comprehensive discussions of the most significant areas of pharmacological research, written by leading international authorities. Each volume in the series represents the most informative and contemporary account of its subject available, making it an unrivalled reference source.