人类肠道微生物群与罕见疾病的关系:近距离窥视。

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL
Souvik Roy, Sagnik Nag, Ankita Saini, Lopamudra Choudhury
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引用次数: 3

摘要

人体内大约有1014个属于不同微生物群的细胞。细菌的数量超过了居住在我们胃肠道(GIT)中的原生动物、真菌和病毒,它们通常被称为“人类肠道微生物群”。当宿主和肠道微生物群之间的平衡关系被破坏时,就会发生生态失调,改变那里通常的微生物种群。这增加了宿主对病原体的易感性,并增加了其发病的机会。这是因为肠道微生物群在人体健康中起着重要作用;它影响着从结直肠癌到与神经系统、自身免疫、代谢和遗传相关的GIT疾病的进展。罕见病是一种致命的持续性疾病,每5000人中有2-3人受到影响。本文综述了人类罕见的神经、自身免疫、心脏代谢和遗传疾病,重点讨论了这些疾病与肠道微生物群之间的基本机制。10种罕见疾病,包括儿童克罗恩病(PCD)、扁平苔藓(LP)、低磷脂酶(HPP)、椎间盘炎、Cogan综合征、软下疳病、Sennetsu热、急性胆囊炎(AC)、Grave's病(GD)和热带口疮(TS),是突出的关键例子,以及针对它们的个性化治疗。这种医学方法解决了个体的遗传和基因组病理学,并以特定和有效的治疗方法处理疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of human gut microbiota with rare diseases: A close peep through.

The human body harbors approximately 1014 cells belonging to a diverse group of microorganisms. Bacteria outnumbers protozoa, fungi and viruses inhabiting our gastrointestinal tract (GIT), commonly referred to as the "human gut microbiome". Dysbiosis occurs when the balanced relationship between the host and the gut microbiota is disrupted, altering the usual microbial population there. This increases the susceptibility of the host to pathogens, and chances of its morbidity. It is due to the fact that the gut microbiome plays an important role in human health; it influences the progression of conditions varying from colorectal cancer to GIT disorders linked with the nervous system, autoimmunity, metabolism and inheritance. A rare disease is a lethal and persistent condition affecting 2-3 people per 5,000 populaces. This review article intends to discuss such rare neurological, autoimmune, cardio-metabolic and genetic disorders of man, focusing on the fundamental mechanism that links them with their gut microbiome. Ten rare diseases, including Pediatric Crohn's disease (PCD), Lichen planus (LP), Hypophosphatasia (HPP), Discitis, Cogan's syndrome, Chancroid disease, Sennetsu fever, Acute cholecystitis (AC), Grave's disease (GD) and Tropical sprue (TS) stands to highlight as key examples, along with personalized therapeutics meant for them. This medicinal approach addresses the individual's genetic and genomic pathography, and tackles the illness with specific and effective treatments.

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来源期刊
Intractable & rare diseases research
Intractable & rare diseases research MEDICINE, GENERAL & INTERNAL-
CiteScore
2.10
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29
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