口腔扁平苔藓:诊断与管理的最新进展。

IF 8.6 1区 医学 Q1 DERMATOLOGY
Agathe Louisy, Eiryann Humbert, Mahtab Samimi
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引用次数: 0

摘要

口腔扁平苔藓(OLP)是一种慢性炎症性疾病,其发病机制是T细胞介导的上皮细胞对未知抗原的炎症反应。这种疾病会间歇性发作,并表现出多形性临床特征(网状、糜烂、萎缩、斑块、丘疹、牛皮癣等)。一旦发病,症状会因临床表现而异,从不适到剧痛不等。外用超强皮质类固醇激素是治疗症状性复发的一线疗法,而二线/三线疗法范围广泛,包括外用降钙素抑制剂、全身用皮质类固醇激素、全身用维甲酸、外用/全身用免疫调节剂等。约有 1%的患者会转变为鳞状细胞癌,因此有必要对患者进行随访,以发现这种转变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Oral Lichen Planus: An Update on Diagnosis and Management

Oral Lichen Planus: An Update on Diagnosis and Management

Oral lichen planus (OLP) is a chronic inflammatory disease whose pathogenesis involves a T-cell mediated, epithelium-directed inflammation in response to unknown antigen(s). The disease evolves by intermittent flares and displays polymorphous clinical features (reticular, erosive, atrophic, plaque, papular, bullous, etc.). When present, symptoms vary depending on the clinical form and range from discomfort to severe pain. Topical superpotent corticosteroids constitute the first-line treatment of symptomatic flares, whereas a wide range of second/third-line treatments are available among topical calcineurin inhibitors, systemic corticosteroids, systemic retinoids, topical/systemic immunomodulators, etc. Follow-up of patients is necessary to detect transformation into squamous cell carcinoma, occurring in approximately 1% of patients.

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来源期刊
CiteScore
15.20
自引率
2.70%
发文量
84
审稿时长
>12 weeks
期刊介绍: The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.
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