COVID-19加强疫苗接种后迟发性肉芽肿间质性肾炎病例报告及文献复习。

IF 1.1 4区 医学 Q3 UROLOGY & NEPHROLOGY
Keshav Ghanekar, Hrishikesh Ghanekar, Ramesh Saxena
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引用次数: 1

摘要

为抗击冠状病毒大流行,已经接种了数十亿剂COVID-19疫苗。虽然该疫苗一般耐受性良好,但仍有几例新发或复发的肾小球肾炎病例报道。相比之下,接种后小管间质性肾炎(TIN)很少报道,主要是在第一剂或第二剂疫苗之后。COVID-19加强疫苗接种后急性间质性肾炎尚未见报道。我们报告一例急性肉芽肿性TIN后不久加强剂量的现代疫苗。我们的病人在接种前两剂疫苗后没有出现肾损伤的临床证据。强化疫苗接种1个月后偶见肾功能不全。患者对类固醇有反应,肾功能迅速改善。虽然很难确定疫苗接种与TIN发展之间的因果关系,但重要的是要警惕疫苗的这种延迟副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Late onset granulomatous interstitial nephritis after booster dose of COVID-19 vaccination: Case report and review of literature.

Billions of doses of COVID-19 vaccine have been administered to combat the coronavirus pandemic. Though the vaccine is generally well tolerated, several cases of new onset or relapsing glomerulonephritis have been reported. In comparison, post-vaccination tubulointerstitial nephritis (TIN) has rarely been reported, mostly after the first or the second dose of the vaccine. Acute interstitial nephritis after booster dose of COVID-19 vaccination has not yet been reported. We report a case of acute granulomatous TIN shortly after the booster dose of Moderna vaccine. Our patient had no clinical evidence of renal injury after the first two doses of vaccine. Renal dysfunction was incidentally observed ~ 1 month after the booster dose of vaccine. The patient responded to steroids with rapid improvement in kidney function. While it is difficult to ascertain the causal relationship between the vaccination and development of TIN, it is important to be vigilant about such delayed side effects of the vaccine.

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来源期刊
Clinical nephrology
Clinical nephrology 医学-泌尿学与肾脏学
CiteScore
2.10
自引率
9.10%
发文量
138
审稿时长
4-8 weeks
期刊介绍: Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.
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