新鲜胚胎移植与冻融胚胎移植妊娠和新生儿结局的比较。

IF 0.8 4区医学 Q4 CRITICAL CARE MEDICINE

Therapeutic hypothermia and temperature management Pub Date : 2023-09-01 DOI:10.1089/ther.2022.0045

Man Chen, Zhi-Ling Li, Hong Lin, Ru-Bin Xia, Yu-Lian Wang

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引用次数: 0

摘要

本研究比较了新鲜胚胎移植和冻融胚胎移植(FET)的妊娠和新生儿结局。这些患者分为两组:新鲜胚胎移植组和FET组。比较两组间的一般情况、妊娠结局和新生儿结局。并探讨了胎儿巨大儿发生的影响因素。与新鲜胚胎移植组相比，FET组的平均年龄(32.59±4.77∶31.90±4.71,p p p > 0.05)显著高于新鲜胚胎移植组。FET组与新鲜胚胎移植组相比，单胎活产平均出生体重、剖宫产率、巨大儿发生率显著升高，低出生体重发生率显著降低。logistic分析显示，胎儿巨大儿的发生主要与胚胎移植方案(优势比[OR] = 2.769, 95%可信区间[CI]: 1.246 ~ 6.154, p p p = 0.003)和多胎妊娠(OR = 3.574, 95% CI: 2.616 ~ 4.882, p

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Comparison of Pregnancy and Neonatal Outcomes Between Fresh Embryo Transfer and Frozen-Thawed Embryo Transfer.

This study compared the pregnancy and neonatal outcomes between fresh embryo transfer and frozen-thawed embryo transfer (FET). These patients were split into two groups: the fresh embryo transfer group and the FET group. The general conditions, pregnancy outcomes, and neonatal outcomes between these groups were compared. The influencing factors of fetal macrosomia occurrence were explored as well. Compared with the fresh embryo transfer group, the FET group had a significantly higher mean age (32.59 ± 4.77 vs. 31.90 ± 4.71, p < 0.05) and lower multiple pregnancy rate (21.2% vs. 26.9%, p < 0.05). There was no significant difference in the incidence of congenital anomalies of neonates between the two groups (1.32% vs. 0.37%, p > 0.05). In the FET group, compared with the fresh embryo transfer group, the mean birth weight of singleton live births, the cesarean section rate, and the incidence of fetal macrosomia were significantly increased, while the incidence of low birth weight was significantly decreased. The logistic analysis showed that the occurrence of fetal macrosomia was primarily associated with the embryo transfer protocol (odds ratio [OR] = 2.769, 95% confidence interval [CI]: 1.246-6.154, p < 0.05), endometrial thickness (OR = 1.144, 95% CI: 1.043-1.256, p < 0.05), and gestational age (OR = 1.710, 95% CI: 1.338-2.184, p < 0.05). Macrosomia (OR = 2.938, 95% CI: 1.436-6.010, p = 0.003) and multiple pregnancy (OR = 3.574, 95% CI: 2.616-4.882, p < 0.001) significantly increased the cesarean section rate. The risk of fetal macrosomia and congenital anomalies in the offspring of the fresh embryo transfer group was lower than that in the offspring of the FET group, we preferred to fresh embryo transfer for patients with assisted reproductive technologies. FET should be used as supplementary therapeutic strategy with strengthened pregnancy management and screening to reduce the occurrence of birth defects in newborns.

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来源期刊

Therapeutic hypothermia and temperature management CRITICAL CARE MEDICINE-

CiteScore

2.50

自引率

8.30%

发文量

期刊介绍： Therapeutic Hypothermia and Temperature Management is the first and only journal to cover all aspects of hypothermia and temperature considerations relevant to this exciting field, including its application in cardiac arrest, spinal cord and traumatic brain injury, stroke, burns, and much more. The Journal provides a strong multidisciplinary forum to ensure that research advances are well disseminated, and that therapeutic hypothermia is well understood and used effectively to enhance patient outcomes. Novel findings from translational preclinical investigations as well as clinical studies and trials are featured in original articles, state-of-the-art review articles, protocols and best practices. Therapeutic Hypothermia and Temperature Management coverage includes: Temperature mechanisms and cooling strategies Protocols, risk factors, and drug interventions Intraoperative considerations Post-resuscitation cooling ICU management.