细胞外囊泡在神经退行性疾病中的作用研究进展。

IF 10.8 1区 医学 Q1 NEUROSCIENCES
Zhengzhe Li, Xiaoling Wang, Xiaoxing Wang, Xiaomei Yi, Yin Kwan Wong, Jiyang Wu, Fangfang Xie, Die Hu, Qi Wang, Jigang Wang, Tianyu Zhong
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引用次数: 2

摘要

神经退行性疾病,如阿尔茨海默病、帕金森病、肌萎缩侧索硬化症和亨廷顿病,影响着全世界数百万人。人们在疾病相关的研究上投入了巨大的努力,但在诊断和治疗方法上却很少取得突破。细胞外囊泡(EVs)是异质细胞衍生的膜结构,产生于内体系统或直接从质膜分离。电动汽车含有许多生物分子,包括蛋白质、核酸和脂质,它们可以在不同的细胞、组织或器官之间转移,从而在正常和病理过程中调节细胞之间的跨器官通讯。最近,EVs已被证明参与神经退行性疾病的各个方面。EVs的异常分泌和水平与神经退行性疾病的发病密切相关,并有助于疾病的进展。许多研究已经提出ev作为神经退行性疾病的治疗靶点或生物标志物。本文就ev在几种神经退行性疾病病理过程中的研究进展进行综述和讨论。此外,我们概述了ev在神经退行性疾病中的作用及其治疗潜力的最新研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Research progress on the role of extracellular vesicles in neurodegenerative diseases.

Research progress on the role of extracellular vesicles in neurodegenerative diseases.

Research progress on the role of extracellular vesicles in neurodegenerative diseases.

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease, affect millions of people worldwide. Tremendous efforts have been put into disease-related research, but few breakthroughs have been made in diagnostic and therapeutic approaches. Extracellular vesicles (EVs) are heterogeneous cell-derived membrane structures that arise from the endosomal system or are directly separated from the plasma membrane. EVs contain many biomolecules, including proteins, nucleic acids, and lipids, which can be transferred between different cells, tissues, or organs, thereby regulating cross-organ communication between cells during normal and pathological processes. Recently, EVs have been shown to participate in various aspects of neurodegenerative diseases. Abnormal secretion and levels of EVs are closely related to the pathogenesis of neurodegenerative diseases and contribute to disease progression. Numerous studies have proposed EVs as therapeutic targets or biomarkers for neurodegenerative diseases. In this review, we summarize and discuss the advanced research progress on EVs in the pathological processes of several neurodegenerative diseases. Moreover, we outline the latest research on the roles of EVs in neurodegenerative diseases and their therapeutic potential for the diseases.

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来源期刊
Translational Neurodegeneration
Translational Neurodegeneration Neuroscience-Cognitive Neuroscience
CiteScore
19.50
自引率
0.80%
发文量
44
审稿时长
10 weeks
期刊介绍: Translational Neurodegeneration, an open-access, peer-reviewed journal, addresses all aspects of neurodegenerative diseases. It serves as a prominent platform for research, therapeutics, and education, fostering discussions and insights across basic, translational, and clinical research domains. Covering Parkinson's disease, Alzheimer's disease, and other neurodegenerative conditions, it welcomes contributions on epidemiology, pathogenesis, diagnosis, prevention, drug development, rehabilitation, and drug delivery. Scientists, clinicians, and physician-scientists are encouraged to share their work in this specialized journal tailored to their fields.
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