肺血管疾病的影像学——了解右心室-肺动脉耦合。

IF 4.2 2区 医学 Q1 PHYSIOLOGY
Katsiaryna Tsarova, Ashley E Morgan, Lana Melendres-Groves, Majd M Ibrahim, Christy L Ma, Irene Z Pan, Nathan D Hatton, Emily M Beck, Meganne N Ferrel, Craig H Selzman, Dominique Ingram, Ayedh K Alamri, Mark B Ratcliffe, Brent D Wilson, John J Ryan
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引用次数: 3

摘要

右心室(RV)和肺动脉(PA)树是密不可分的,在一个被称为RV-PA耦合的过程中不断地来回传递能量。健康生物体通过调节右心室收缩力、肺血管阻力和顺应性来维持右心室- pa耦合,从而在生命中的许多生理挑战中保持这种关系的最佳平衡。在对心血管疾病的早期适应状态中,例如在舒张性心力衰竭中,rv - pa偶联是通过多种细胞和机械转化来维持的。然而,随着疾病的进展,这些代偿机制失效并变得不适应,导致通常是致命的“解耦”状态。无创成像方式,包括超声心动图、磁共振成像和计算机断层扫描,使我们能够更深入地了解单个患者的耦合状态,在分离发生之前提供预测和潜在的干预措施。在这篇综述中,我们讨论了RV-PA耦合的生理基础,详细阐述了成像技术来确定和量化它,并将这些基本原理与健康和疾病的临床情况联系起来。©2022美国生理学会。中国生物医学工程学报(英文版),2016,31(2):444 - 444。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Imaging in Pulmonary Vascular Disease-Understanding Right Ventricle-Pulmonary Artery Coupling.

The right ventricle (RV) and pulmonary arterial (PA) tree are inextricably linked, continually transferring energy back and forth in a process known as RV-PA coupling. Healthy organisms maintain this relationship in optimal balance by modulating RV contractility, pulmonary vascular resistance, and compliance to sustain RV-PA coupling through life's many physiologic challenges. Early in states of adaptation to cardiovascular disease-for example, in diastolic heart failure-RV-PA coupling is maintained via a multitude of cellular and mechanical transformations. However, with disease progression, these compensatory mechanisms fail and become maladaptive, leading to the often-fatal state of "uncoupling." Noninvasive imaging modalities, including echocardiography, magnetic resonance imaging, and computed tomography, allow us deeper insight into the state of coupling for an individual patient, providing for prognostication and potential intervention before uncoupling occurs. In this review, we discuss the physiologic foundations of RV-PA coupling, elaborate on the imaging techniques to qualify and quantify it, and correlate these fundamental principles with clinical scenarios in health and disease. © 2022 American Physiological Society. Compr Physiol 12: 1-26, 2022.

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来源期刊
CiteScore
10.50
自引率
0.00%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.
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