血液透析患者认知功能障碍的发生率和危险因素:一项系统综述和荟萃分析。

IF 1.4 4区 医学 Q3 UROLOGY & NEPHROLOGY
Seminars in Dialysis Pub Date : 2023-09-01 Epub Date: 2023-08-17 DOI:10.1111/sdi.13171
Jun Liu, Kehong Chen, Jia Chen, Lili Fu, Weiwei Zhang, Jing Lin, Jingfang Wan
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引用次数: 0

摘要

背景:本研究旨在探讨血液透析患者认知功能障碍的发生率和危险因素。方法:检索PubMed、Embase、Cochrane Library和Web of Science数据库,从数据库成立到2022年12月1日,对血液透析与认知功能障碍之间的关系进行临床研究。两名研究人员独立完成了纳入研究的数据提取和偏倚风险评估。所有统计分析均使用STATA15.0软件进行。结果:本荟萃分析纳入了10项研究,共有5535名血液透析患者,即2033名认知功能障碍患者和3502名认知功能正常患者。纳入研究的纽卡斯尔-渥太华量表得分大于5。荟萃分析结果表明,血液透析患者认知功能障碍的发生率为(效应大小 = 51%,95%置信区间[CI][0.33,0.69]),患有认知功能障碍的血液透析患者通常比认知正常的患者年龄大(标准平均差[SMD] = 0.49,95%CI[0.31,0.68])。女性是血液透析患者认知功能障碍的危险因素(相对风险[RR] = 1.21,95%CI[1.04,1.41]);糖尿病(RR = 1.33,95%可信区间[1.04,1.71])和中风(RR = 1.66,95%可信区间[1.08,2.55])增加了血液透析患者认知功能障碍的发生率。结论:与血液透析相关的认知功能障碍最重要的危险因素可能是女性、老年、糖尿病和中风。应密切关注此类患者,以便及早预防。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incidence and risk factors of cognitive dysfunction in hemodialysis patients: A systematic review and meta-analysis.

Background: The study aims to explore the incidence and risk factors of cognitive dysfunction in hemodialysis patients.

Methods: PubMed, Embase, Cochrane Library, and Web of Science databases were searched for clinical studies on the association between hemodialysis and cognitive dysfunction from the database's inception to 1 December 2022. Two researchers independently completed data extraction and risk of bias assessments for the included studies. All statistical analyses were performed using STATA15.0 software.

Results: Ten studies were included in this meta-analysis, with a total of 5535 hemodialysis patients, that is, 2033 patients with cognitive dysfunction and 3502 patients with normal cognitive function. The Newcastle-Ottawa Scale scores of the included studies were greater than 5. Meta-analysis results suggested that the incidence of cognitive dysfunction in hemodialysis patients was (effect size = 51%, 95% confidence interval [CI] [0.33, 0.69]), and hemodialysis patients with cognitive dysfunction were often older than those with normal cognition (standard mean difference [SMD] = 0.49, 95% CI [0.31, 0.68]). Female gender was a risk factor for cognitive dysfunction in hemodialysis patients (relative risk [RR] = 1.21, 95% CI [1.04, 1.41]); diabetes (RR = 1.33, 95% CI [1.04, 1.71]) and stroke (RR = 1.66, 95% CI [1.08, 2.55]) increased the incidence of cognitive dysfunction in hemodialysis patients.

Conclusions: The most important risk factors for cognitive dysfunction associated with hemodialysis might be female gender, old age, diabetes, and stroke. Close attention should be paid to such patients for early prevention.

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来源期刊
Seminars in Dialysis
Seminars in Dialysis 医学-泌尿学与肾脏学
CiteScore
3.00
自引率
6.20%
发文量
91
审稿时长
4-8 weeks
期刊介绍: Seminars in Dialysis is a bimonthly publication focusing exclusively on cutting-edge clinical aspects of dialysis therapy. Besides publishing papers by the most respected names in the field of dialysis, the Journal has unique useful features, all designed to keep you current: -Fellows Forum -Dialysis rounds -Editorials -Opinions -Briefly noted -Summary and Comment -Guest Edited Issues -Special Articles Virtually everything you read in Seminars in Dialysis is written or solicited by the editors after choosing the most effective of nine different editorial styles and formats. They know that facts, speculations, ''how-to-do-it'' information, opinions, and news reports all play important roles in your education and the patient care you provide. Alternate issues of the journal are guest edited and focus on a single clinical topic in dialysis.
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