食管切除术后低执行率对癌症的预后价值。

Q4 Medicine
Journal of Chest Surgery Pub Date : 2023-11-05 Epub Date: 2023-09-12 DOI:10.5090/jcs.23.050
Minsang Kang, Woojung Kim, Chang Hyun Kang, Kwon Joong Na, Samina Park, Hyun Joo Lee, In Kyu Park, Young Tae Kim
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引用次数: 2

摘要

背景:少复发的概念尚未广泛应用于食管癌症。本研究旨在确定食管癌症复发次数的预后意义。方法:纳入接受R0或R1根治性食管切除术并确认复发的鳞状细胞癌患者。该研究包括2001年3月至2019年12月的321名符合条件的参与者。研究复发次数与复发后生存率之间的关系。结果:平均年龄为63.8±8.1岁,大多数参与者(97.5%)为男性。复发的中位时间为10.7个月,复发后的中位生存时间为8.8个月。同时发生局部、区域和远处的多发复发是常见的(38%)。就复发次数而言,单次复发最常见(38.3%),复发后生存率最高(中位,17.1个月;P结论:食管切除术后,复发次数是影响食管癌症患者复发后生存率的最重要风险因素。在食管癌症中,少发复发可定义为三次或三次以下转移的复发。如果发生少发复发,可能建议进行更强化的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Prognostic Value of Oligo-Recurrence Following Esophagectomy for Esophageal Cancer.

Background: The concept of oligo-recurrence has not been generally applied in esophageal cancer. This study aimed to determine the prognostic significance of the number of recurrences in esophageal cancer.

Methods: Patients with squamous cell carcinoma who underwent curative esophagectomy with R0 or R1 resection and who experienced a confirmed recurrence were included. The study included 321 eligible participants from March 2001 to December 2019. The relationship between the number of recurrences and post-recurrence survival was investigated.

Results: The mean age was 63.8±8.1 years, and the majority of the participants (97.5%) were men. The median time to recurrence was 10.7 months, and the median survival time after recurrence was 8.8 months. Multiple recurrences with simultaneous local, regional, and distant locations were common (38%). In terms of the number of recurrences, single recurrences were the most common (38.3%) and had the best post-recurrence survival rate (median, 17.1 months; p<0.001). Patients with 2 or 3 recurrences showed equivalent survival to each other and longer survival than those with 4 or more (median, 9.4 months; p<0.001). In the multivariable analysis, the significant predictors of post-recurrence survival were body mass index, minimally invasive esophagectomy, N stage, R0 resection, post-recurrence treatment, and the number of recurrences (p<0.05).

Conclusion: After esophagectomy, the number of recurrences was the most significant risk factor influencing post-recurrence survival in patients with esophageal cancer. In esophageal cancer, oligo-recurrence can be defined as a recurrence with three or fewer metastases. More intensive treatment might be recommended if oligo-recurrence occurs.

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来源期刊
Journal of Chest Surgery
Journal of Chest Surgery Medicine-Surgery
CiteScore
0.80
自引率
0.00%
发文量
76
审稿时长
7 weeks
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