囊性纤维化患者糖耐量异常和糖尿病的筛查策略

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Laurence Weiss , Philippe Reix , Helen Mosnier-Pudar , Olivia Ronsin , Jacques Beltrand , Quitterie Reynaud , Laurent Mely , Pierre-Régis Burgel , Nathalie Stremler , Luc Rakotoarisoa , Alfonso Galderisi , Kevin Perge , Nathalie Bendelac , Michel Abely , Laurence Kessler
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引用次数: 2

摘要

囊性纤维化患者预期寿命的增加带来了新的合并症,尤其是糖尿病。糖耐量异常的逐渐发展意味着30%至40%的成年人将患有糖尿病。囊性纤维化相关糖尿病是这些患者护理中的一个主要挑战,因为它是疾病各个阶段的发病率和死亡率因素。从儿童期到糖尿病前期观察到的早期糖耐量异常也与不良的肺部和营养结果有关。长期的无症状期证明了从10岁开始每年进行口服葡萄糖耐量测试的系统筛查是合理的。然而,这一策略没有考虑囊性纤维化患者的新临床特征、最近对糖耐量异常的病理生理学知识以及糖尿病新诊断工具的出现。在这篇论文中,我们总结了在当前新患者情况下筛查的挑战——怀孕、进行移植或正在接受纤维化传导跨膜调节调节剂治疗的患者——并对囊性纤维化相关糖尿病的各种筛查方法进行了总结,包括其应用,局限性和实际意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Screening strategies for glucose tolerance abnormalities and diabetes in people with cystic fibrosis

The increase in life expectancy of patients with cystic fibrosis has come with new comorbidities, particularly diabetes. The gradual development of glucose tolerance abnormalities means that 30 to 40% of adults will be diabetic. Cystic fibrosis–related diabetes is a major challenge in the care of these patients because it is a morbidity and mortality factor at all stages of the disease. Early glucose tolerance abnormalities observed from childhood, before the stage of diabetes, are also associated with a poor pulmonary and nutritional outcome. The long asymptomatic period justifies systematic screening with an annual oral glucose tolerance test from the age of 10 years. However, this strategy does not take into account the new clinical profiles of patients with cystic fibrosis, recent pathophysiological knowledge of glucose tolerance abnormalities, and the emergence of new diagnostic tools in diabetology. In this paper, we summarise the challenges of screening in the current context of new patient profiles – patients who are pregnant, have transplants, or are being treated with fibrosis conductance transmembrane regulator modulators – and put forward an inventory of the various screening methods for cystic fibrosis–related diabetes, including their applications, limitations and practical implications.

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来源期刊
Diabetes & metabolism
Diabetes & metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.20%
发文量
86
审稿时长
13 days
期刊介绍: A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.
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