顺铂诱导耳毒性:一种解决古老问题的新方法。

IF 1.7 3区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Pharmacogenetics and genomics Pub Date : 2023-07-01 DOI:10.1097/FPC.0000000000000497

Nabil E Omar, Hazem Elewa

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引用次数: 0

摘要

由于针对顺铂诱导的耳毒性(CIO)的药理学耳保护剂的缺乏，研究人员发现自己不得不寻找和导航所有可能的策略来确定预防CIO的方法。其中一个很有前途的策略是药物基因组学的实施。该策略旨在识别和检测高风险遗传变异，以定制顺铂治疗，以达到最佳的生存结果和最小的耳毒性风险。

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Cisplatin-induced ototoxicity: a novel approach to an ancient problem.

With the scarcity of pharmacological otoprotective agents against cisplatin-induced ototoxicity (CIO), researchers find themselves compelled to look at and navigate all possible strategies to identify ways to prevent CIO. One of these promising strategies is pharmacogenomic implementation. This strategy aims for identifying and detecting high-risk genetic variants to tailor cisplatin therapy to reach the best survival outcomes with the least risk of ototoxicity.

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来源期刊

Pharmacogenetics and genomics 医学-生物工程与应用微生物

CiteScore

3.20

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Pharmacogenetics and Genomics is devoted to the rapid publication of research papers, brief review articles and short communications on genetic determinants in response to drugs and other chemicals in humans and animals. The Journal brings together papers from the entire spectrum of biomedical research and science, including biochemistry, bioinformatics, clinical pharmacology, clinical pharmacy, epidemiology, genetics, genomics, molecular biology, pharmacology, pharmaceutical sciences, and toxicology. Under a single cover, the Journal provides a forum for all aspects of the genetics and genomics of host response to exogenous chemicals: from the gene to the clinic.