[A Review of the Book "Minamata Disease and the Responsibility of Medical Authorities"].

Even today, more than 60 years after the discovery of Minamata disease, many controversies continue to arise from various viewpoints. Recently, Dr. Shigeru Takaoka has published a book entitled "Minamata Disease and the Responsibility of Medical authorities" as a summary of his and colleagues' previous works in which he presented their objections to past academic theories. We, who were also engaged in this research at Kumamoto University, would like to address some substantial viewpoints. Drs. Nishimura and Okamoto clarified why a series of cases that were clearly Minamata disease were found only in the Minamata plant from late 1950 to 1975, even though many acetaldehyde plants have been operating in Japan for many years. Dr. Takaoka ignored this very important issue and we point out the lack of reliability of his data from their health examination of "10,000" people. From the pathology perspective, Dr. Takaoka mis-understood the location and plasticity of neurons. From a clinical viewpoint, he mentioned the poor evidence for the characteristics and courses of the patients' clinical symptoms.