伊朗感染耐碳青霉烯类铜绿假单胞菌住院患者死亡率的危险因素

IF 1.7 Q3 INFECTIOUS DISEASES
GERMS Pub Date : 2022-09-01 DOI:10.18683/germs.2022.1338
Younes Khalili, Pooya Omidnia, Hamid Reza Goli, Sajjad Zamanlou, Farhad Babaie, Abed Zahedi Bialvaei
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引用次数: 0

摘要

近年来,碳青霉烯耐药铜绿假单胞菌(CRPA)感染导致的死亡率在全球范围内呈上升趋势。在许多研究中,与伊朗医院环境相关的危险因素和菌株抗性机制的作用尚不清楚。方法:对伊朗西北部7家主要医院分离的连续非重复性CRPA感染患者进行回顾性研究。我们评估了患者死亡或生存的不同危险因素和细菌特征。结果:本研究从7家医院收治的患者中分离出116株CRPA。41例(35.3%)患者纳入死亡危险因素研究。与死亡率相关的重要危险因素包括感染部位、不同病房的住院情况、侵入性器械的使用以及碳青霉烯类耐药机制的类型。结论:入住ICU、机械通气和胸管的使用以及感染耐药菌株是增加CRPA感染死亡率的最重要因素。这些结果提示临床医生应重视抗生素和侵入性手术的正确使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk factors for mortality in hospitalized patients infected with carbapenem-resistant Pseudomonas aeruginosa in Iran.

Introduction: Mortality due to carbapenem-resistant Pseudomonas aeruginosa (CRPA) infection has increased worldwide in recent years. The risk factors associated with hospital settings in Iran and the role of strain resistance mechanisms in many studies are unclear.

Methods: A retrospective study was conducted on consecutive non-repetitive patients with CRPA infections isolated from seven major hospitals from northwest of Iran. We evaluated different risk factors and characteristics of bacteria for the death or survival of patients.

Results: In this study, 116 CRPA isolates were obtained from patients admitted to seven hospitals. Forty-one (35.3%) patients were enrolled in the study of mortality risk factors. Significant risk factors associated with mortality included the site of infection, hospitalization in different wards, the use of invasive devices, and the type of carbapenem resistance mechanisms.

Conclusions: ICU admission, the use of mechanical ventilation and chest tube and infection with pandrug-resistant strains were the most important factors in increasing mortality due to CRPA infection. These results suggested that the clinicians should emphasize the proper use of antibiotic and invasive procedures.

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来源期刊
GERMS
GERMS INFECTIOUS DISEASES-
CiteScore
2.80
自引率
5.00%
发文量
36
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