Chuanjun Yan, Xianliang Wang, Aiping Wen, Jingyue Luo, Siyu Zhang, Pei Wang, Jie Li
{"title":"IPSA和HIPO算法在腔内/间质联合近距离宫颈癌治疗中的剂量学和放射生物学模型的比较分析。","authors":"Chuanjun Yan, Xianliang Wang, Aiping Wen, Jingyue Luo, Siyu Zhang, Pei Wang, Jie Li","doi":"10.5114/jcb.2023.128894","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To compare inverse planning simulated annealing (IPSA) and hybrid inverse planning optimization (HIPO) using dosimetric and radiobiological models, and provide a basis for selecting the optimization method for cervical cancer.</p><p><strong>Material and methods: </strong>This was a retrospective study including 32 patients with radical cervical cancer. Brachytherapy treatment plans were re-optimized using IPSA, HIPO1 (with a locked uterine tube), and HIPO2 (with an unlocked uterine tube). Dosimetric data, including isodose lines, HR-CTV (D<sub>100</sub>, V<sub>150%</sub>, V<sub>200%</sub>, HI, and CI), and (bladder, rectum, and intestines) D<sub>1cc</sub>, D<sub>2cc</sub> for organs at risk (OARs) were also collected. Additionally, TCP, NTCP, BED, and EUBED were calculated, and differences were analyzed using matched samples <i>t</i>-test and Friedman test.</p><p><strong>Results: </strong>Compared with IPSA and HIPO2, HIPO1 had better V<sub>150%</sub> and V<sub>200%</sub> (<i>p</i> < 0.05). Compared with IPSA and HIPO1, HIPO2 had better D<sub>100</sub> and CI (<i>p</i> < 0.05). The doses to the bladder D<sub>1cc</sub> (4.72 ±0.33 Gy)/D<sub>2cc</sub> (4.47 ±0.29 Gy) and rectum D<sub>1cc</sub> (4.50 ±0.61 Gy)/D<sub>2cc</sub> (4.11 ±0.63 Gy) were lower in HIPO2 than in IPSA and HIPO1. EUBEDs for HR-CTV were higher in HIPO1 and HIPO2 than in IPSA by 1.39-1.63%. However, TCPs were not remarkably different among the three plans (<i>p</i> > 0.05). Also, the NTCP for the bladder was lower in HIPO2 than in IPSA and HIPO1 by 13.04% and 16.67%, respectively.</p><p><strong>Conclusions: </strong>Although the dosimetric parameters of IPSA, HIPO1, and HIPO2 are comparable, HIPO2 provides better dose conformability and lower NTCP. Therefore, HIPO2 is recommended as an optimization algorithm in IC/ISBT for cervical cancer.</p>","PeriodicalId":51305,"journal":{"name":"Journal of Contemporary Brachytherapy","volume":"15 3","pages":"212-219"},"PeriodicalIF":1.1000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/e3/JCB-15-50904.PMC10324594.pdf","citationCount":"0","resultStr":"{\"title\":\"Comparative analysis of dosimetric and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer.\",\"authors\":\"Chuanjun Yan, Xianliang Wang, Aiping Wen, Jingyue Luo, Siyu Zhang, Pei Wang, Jie Li\",\"doi\":\"10.5114/jcb.2023.128894\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To compare inverse planning simulated annealing (IPSA) and hybrid inverse planning optimization (HIPO) using dosimetric and radiobiological models, and provide a basis for selecting the optimization method for cervical cancer.</p><p><strong>Material and methods: </strong>This was a retrospective study including 32 patients with radical cervical cancer. Brachytherapy treatment plans were re-optimized using IPSA, HIPO1 (with a locked uterine tube), and HIPO2 (with an unlocked uterine tube). Dosimetric data, including isodose lines, HR-CTV (D<sub>100</sub>, V<sub>150%</sub>, V<sub>200%</sub>, HI, and CI), and (bladder, rectum, and intestines) D<sub>1cc</sub>, D<sub>2cc</sub> for organs at risk (OARs) were also collected. Additionally, TCP, NTCP, BED, and EUBED were calculated, and differences were analyzed using matched samples <i>t</i>-test and Friedman test.</p><p><strong>Results: </strong>Compared with IPSA and HIPO2, HIPO1 had better V<sub>150%</sub> and V<sub>200%</sub> (<i>p</i> < 0.05). Compared with IPSA and HIPO1, HIPO2 had better D<sub>100</sub> and CI (<i>p</i> < 0.05). The doses to the bladder D<sub>1cc</sub> (4.72 ±0.33 Gy)/D<sub>2cc</sub> (4.47 ±0.29 Gy) and rectum D<sub>1cc</sub> (4.50 ±0.61 Gy)/D<sub>2cc</sub> (4.11 ±0.63 Gy) were lower in HIPO2 than in IPSA and HIPO1. EUBEDs for HR-CTV were higher in HIPO1 and HIPO2 than in IPSA by 1.39-1.63%. However, TCPs were not remarkably different among the three plans (<i>p</i> > 0.05). Also, the NTCP for the bladder was lower in HIPO2 than in IPSA and HIPO1 by 13.04% and 16.67%, respectively.</p><p><strong>Conclusions: </strong>Although the dosimetric parameters of IPSA, HIPO1, and HIPO2 are comparable, HIPO2 provides better dose conformability and lower NTCP. 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Comparative analysis of dosimetric and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer.
Purpose: To compare inverse planning simulated annealing (IPSA) and hybrid inverse planning optimization (HIPO) using dosimetric and radiobiological models, and provide a basis for selecting the optimization method for cervical cancer.
Material and methods: This was a retrospective study including 32 patients with radical cervical cancer. Brachytherapy treatment plans were re-optimized using IPSA, HIPO1 (with a locked uterine tube), and HIPO2 (with an unlocked uterine tube). Dosimetric data, including isodose lines, HR-CTV (D100, V150%, V200%, HI, and CI), and (bladder, rectum, and intestines) D1cc, D2cc for organs at risk (OARs) were also collected. Additionally, TCP, NTCP, BED, and EUBED were calculated, and differences were analyzed using matched samples t-test and Friedman test.
Results: Compared with IPSA and HIPO2, HIPO1 had better V150% and V200% (p < 0.05). Compared with IPSA and HIPO1, HIPO2 had better D100 and CI (p < 0.05). The doses to the bladder D1cc (4.72 ±0.33 Gy)/D2cc (4.47 ±0.29 Gy) and rectum D1cc (4.50 ±0.61 Gy)/D2cc (4.11 ±0.63 Gy) were lower in HIPO2 than in IPSA and HIPO1. EUBEDs for HR-CTV were higher in HIPO1 and HIPO2 than in IPSA by 1.39-1.63%. However, TCPs were not remarkably different among the three plans (p > 0.05). Also, the NTCP for the bladder was lower in HIPO2 than in IPSA and HIPO1 by 13.04% and 16.67%, respectively.
Conclusions: Although the dosimetric parameters of IPSA, HIPO1, and HIPO2 are comparable, HIPO2 provides better dose conformability and lower NTCP. Therefore, HIPO2 is recommended as an optimization algorithm in IC/ISBT for cervical cancer.
期刊介绍：
The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.
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