The pathogenic pathways of cardiovascular disease in perimenopausal women.

Introduction: Menopause is associated with disturbed cardiovascular health. The objective of the study was to compare the effect of hormonal replacement therapy (HRT) and its combination with diet, L-arginine, and xylitol solutions on metabolic processes and cardiovascular health in perimenopausal women.

Material and methods: In total 106 women were enrolled in the cross-sectional study. The 36 patients of Group II received HRT. 35 women who had been prescribed additionally to HRT a diet, L-arginine, and also xylitol were included in Group III. 35 healthy reproductive-aged women were included in Group I (control). The variables body mass index (BMI), heart rate (HR), blood pressure (BP), lipid and carbohydrate metabolism and C-reactive protein, and menopausal Cooperman's score were determined before and after the 3-month program.

Results: The obtained results showed the homogeneity of average age, BMI, HR, BP, and Cooperman's score in Group II and Group III before inclusion in the study. But several variables changed significantly after a 3-month period. The study showed the effect of the 3-month program on BMI and Cooperman's score. We also found the restoration of the lipid profiles in Group III. The patients of perimenopausal age featured elevated levels of insulin and C-RP (C-reactive protein). The restoration of levels of insulin and CRP occurred in the process of the 3-month program.

Conclusions: The use of a 3-month program including diet, xylitol, and L-arginine solutions contributed to the reduction of Cooperman's score, chronic inflammation, and restoration of lipid and carbohydrate metabolism.