Pierce Boyne, Allison Miller, Owen Kubalak, Caroline Mink, Darcy S Reisman, George Fulk
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Pooled estimates were calculated for mean changes, AE relative risks, and the standard deviation of response (SD response ) to LT mv versus control groups, stratified by study chronicity where possible.</p><p><strong>Results: </strong>There were 19 eligible studies (total N = 1096): 14 in chronic stroke (N = 839) and 5 in subacute stroke (N = 257). Compared with control interventions, LT mv yielded significantly greater increases in CGS (chronic, +0.06 m/s [95% confidence interval (CI), 0.01-0.10]; subacute, +0.16 [0.12-0.19]; subacute vs chronic, P = 0.03), FGS (chronic, +0.07 m/s [0.02-0.13]; subacute, +0.21 [0.01, 0.41]; P = 0.04), and 6MWT (chronic, +33 m [24-42]; subacute, +51 [26-77]; P = 0.054) but not steps/day (+260 [-1159 to 1679]). There were no treatment-related serious AEs among 398 LT mv participants in 14 AE-reporting studies. SD response estimates indicated substantial response variability: CGS, 0.11 m/s [0.00-0.15]; FGS, 0.14 m/s [-0.00 to 0.20]; and 6MWT, 41 m [27-51].</p><p><strong>Discussion and conclusions: </strong>LT mv improves mean walking capacity outcomes in subacute and chronic stroke and does not appear to have high risk of serious harm. 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引用次数: 0
摘要
背景和目的：本荟萃分析量化了中强度运动训练（LT mv）对亚急性和慢性卒中患者步行结果的平均影响，以及 LT mv 反应的变异程度：在数据库中搜索了比较 LT mv 与无干预、非步态干预或低强度步态训练的随机试验。提取了舒适步态速度（CGS）、最快步态速度（FGS）、6 分钟步行测试（6MWT）、步行活动（每天步数）和不良反应/事件（AE）数据。计算了LT mv与对照组相比的平均变化、AE相对风险和反应标准差（SD反应）的汇总估计值，并尽可能按研究的慢性程度进行分层：符合条件的研究有 19 项（总人数 = 1096）：结果：共有 19 项符合条件的研究（总人数 = 1096 人）：14 项针对慢性中风（人数 = 839 人），5 项针对亚急性中风（人数 = 257 人）。与对照干预相比，LT mv 可显著提高 CGS（慢性，+0.06 m/s[95% 置信区间 (CI)，0.01-0.10]；亚急性，+0.16 [0.12-0.19]；亚急性与慢性相比，P = 0.P=0.03）、FGS（慢性期，+0.07 m/s [0.02-0.13]；亚急性期，+0.21 [0.01, 0.41]；P=0.04）、6MWT（慢性期，+33 m [24-42]；亚急性期，+51 [26-77]；P=0.054），但步数/天（+260 [-1159 to 1679]）没有相关性。在14项AE报告研究的398名LT mv参与者中，没有出现与治疗相关的严重AE。SD 反应估计值表明反应差异很大：CGS，0.11 m/s [0.00-0.15]；FGS，0.14 m/s [-0.00至0.20]；6MWT，41 m [27-51]：LT mv可改善亚急性和慢性卒中患者的平均行走能力，且似乎不会造成严重危害。慢性亚组内部和慢性亚组之间的反应程度各不相同，很少有研究测试了对日常步行活动或非严重AEs的影响。可通过视频摘要了解作者的更多见解（请参阅视频，补充数字内容1，网址：http://links.lww.com/JNPT/A452 ）。
Moderate to Vigorous Intensity Locomotor Training After Stroke: A Systematic Review and Meta-analysis of Mean Effects and Response Variability.
Background and purpose: This meta-analysis quantified mean effects of moderate to vigorous intensity locomotor training (LT mv ) on walking outcomes in subacute and chronic stroke, and the magnitude of variability in LT mv response.
Methods: Databases were searched for randomized trials comparing LT mv with no intervention, nongait intervention, or low-intensity gait training. Comfortable gait speed (CGS), fastest gait speed (FGS), 6-minute walk test (6MWT), walking activity (steps per day), and adverse effect/event (AE) data were extracted. Pooled estimates were calculated for mean changes, AE relative risks, and the standard deviation of response (SD response ) to LT mv versus control groups, stratified by study chronicity where possible.
Results: There were 19 eligible studies (total N = 1096): 14 in chronic stroke (N = 839) and 5 in subacute stroke (N = 257). Compared with control interventions, LT mv yielded significantly greater increases in CGS (chronic, +0.06 m/s [95% confidence interval (CI), 0.01-0.10]; subacute, +0.16 [0.12-0.19]; subacute vs chronic, P = 0.03), FGS (chronic, +0.07 m/s [0.02-0.13]; subacute, +0.21 [0.01, 0.41]; P = 0.04), and 6MWT (chronic, +33 m [24-42]; subacute, +51 [26-77]; P = 0.054) but not steps/day (+260 [-1159 to 1679]). There were no treatment-related serious AEs among 398 LT mv participants in 14 AE-reporting studies. SD response estimates indicated substantial response variability: CGS, 0.11 m/s [0.00-0.15]; FGS, 0.14 m/s [-0.00 to 0.20]; and 6MWT, 41 m [27-51].
Discussion and conclusions: LT mv improves mean walking capacity outcomes in subacute and chronic stroke and does not appear to have high risk of serious harm. Response magnitude varies within and between chronicity subgroups, and few studies have tested effects on daily walking activity or non-serious AEs.Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1 available at: http://links.lww.com/JNPT/A452 ).
期刊介绍：
The Journal of Neurologic Physical Therapy (JNPT) is an indexed resource for dissemination of research-based evidence related to neurologic physical therapy intervention. High standards of quality are maintained through a rigorous, double-blinded, peer-review process and adherence to standards recommended by the International Committee of Medical Journal Editors. With an international editorial board made up of preeminent researchers and clinicians, JNPT publishes articles of global relevance for examination, evaluation, prognosis, intervention, and outcomes for individuals with movement deficits due to neurologic conditions. Through systematic reviews, research articles, case studies, and clinical perspectives, JNPT promotes the integration of evidence into theory, education, research, and practice of neurologic physical therapy, spanning the continuum from pathophysiology to societal participation.
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