用有限吸收时间概念重新检查纳洛酮经鼻和肌肉给药后的药代动力学。

IF 1.9 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Athanasios A Tsekouras, Panos Macheras
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引用次数: 0

摘要

背景和目的:纳洛酮用于阿片类药物过量治疗可通过静脉注射、肌肉注射或鼻内给药。已发表的数据表明,纳洛酮药代动力学的差异取决于给药途径。本研究的目的是分析药代动力学数据,以同样的方式,我们最近成功地应用了有限吸收时间的概念,口服给药的药物配方。方法:利用已建立的模型方程,对24组纳洛酮血药浓度随时间的变化进行最小二乘分析。结果:我们发现,与经典的无限时间的一阶吸收动力学相比,考虑有限时间的零级吸收动力学时,肌内和鼻内给药可以更准确地描述。结论:单室模型适用于大多数病例。双室模型提供了更好的细节,但具有更高的参数不确定性。吸收持续时间可以直接由模型参数确定,因此可以方便地比较给药方式。此外,肌肉注射的精确部位似乎对药物吸收的持续时间有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Re-examining Naloxone Pharmacokinetics After Intranasal and Intramuscular Administration Using the Finite Absorption Time Concept.

Re-examining Naloxone Pharmacokinetics After Intranasal and Intramuscular Administration Using the Finite Absorption Time Concept.

Background and objectives: Naloxone for opioid overdose treatment can be administered by intravenous injection, intramuscular injection, or intranasal administration. Published data indicate differences in naloxone pharmacokinetics depending on the route of administration. The aim of this study was to analyze pharmacokinetic data in the same way that we recently successfully applied the concept of the finite absorption time in orally administered drug formulations.

Methods: Using the model equations already derived, we performed least squares analysis on 24 sets of naloxone concentration in the blood as a function of time.

Results: We found that intramuscular and intranasal administration can be described more accurately when considering zero-order absorption kinetics for finite time compared with classical first order absorption kinetics for infinite time.

Conclusions: One-compartment models work well for most cases. Two-compartment models provide better details, but have higher parameter uncertainties. The absorption duration can be determined directly from the model parameters and thus allow an easy comparison between the ways of administration. Furthermore, the precise site of injection for intramuscular delivery appears to make a difference in terms of the duration of the drug absorption.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
64
审稿时长
>12 weeks
期刊介绍: Hepatology International is a peer-reviewed journal featuring articles written by clinicians, clinical researchers and basic scientists is dedicated to research and patient care issues in hepatology. This journal focuses mainly on new and emerging diagnostic and treatment options, protocols and molecular and cellular basis of disease pathogenesis, new technologies, in liver and biliary sciences. Hepatology International publishes original research articles related to clinical care and basic research; review articles; consensus guidelines for diagnosis and treatment; invited editorials, and controversies in contemporary issues. The journal does not publish case reports.
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