Fabiane Valentini Francisqueti-Ferron, Matheus Antônio Filiol Belin, Thiago Luiz Novaga Palacio, Artur Junio Togneri Ferron, Jéssica Leite Garcia, Juliana Silva Siqueira, Erika Tiemi Nakandakare-Maia, Taynara Aparecida Vieira, Hugo Tadashi Kano, Fernando Moreto, Giuseppina Pace Pereira Lima, Camila Renata Corrêa, Igor Otavio Minatel
{"title":"果糖摄入改变与心血管疾病危险因素相关的生物胺","authors":"Fabiane Valentini Francisqueti-Ferron, Matheus Antônio Filiol Belin, Thiago Luiz Novaga Palacio, Artur Junio Togneri Ferron, Jéssica Leite Garcia, Juliana Silva Siqueira, Erika Tiemi Nakandakare-Maia, Taynara Aparecida Vieira, Hugo Tadashi Kano, Fernando Moreto, Giuseppina Pace Pereira Lima, Camila Renata Corrêa, Igor Otavio Minatel","doi":"10.36660/abc.20220770","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases (CVD) are the major cause of mortality worldwide, whose most prominent risk factor is unhealthy eating habits, such as high fructose intake. Biogenic amines (BAs) perform important functions in the human body. However, the effect of fructose consumption on BA levels is still unclear, as is the association between these and CVD risk factors.</p><p><strong>Objective: </strong>This study aimed to establish the association between BA levels and CVD risk factors in animals that consumed fructose.</p><p><strong>Methods: </strong>Male Wistar rats received standard chow (n=8) or standard chow + fructose in drinking water (30%) (n=8) over a 24-week period. At the end of this period, the nutritional and metabolic syndrome (MS) parameters and plasmatic BA levels were analyzed. A 5% level of significance was adopted.</p><p><strong>Results: </strong>Fructose consumption led to MS, reduced the levels of tryptophan and 5-hydroxitryptophan, and increased histamine. Tryptophan, histamine, and dopamine showed a correlation with metabolic syndrome parameters.</p><p><strong>Conclusion: </strong>Fructose consumption alters BAs associated with CVD risk factors.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263407/pdf/","citationCount":"0","resultStr":"{\"title\":\"Fructose Consumption Alters Biogenic Amines Associated with Cardiovascular Disease Risk Factors.\",\"authors\":\"Fabiane Valentini Francisqueti-Ferron, Matheus Antônio Filiol Belin, Thiago Luiz Novaga Palacio, Artur Junio Togneri Ferron, Jéssica Leite Garcia, Juliana Silva Siqueira, Erika Tiemi Nakandakare-Maia, Taynara Aparecida Vieira, Hugo Tadashi Kano, Fernando Moreto, Giuseppina Pace Pereira Lima, Camila Renata Corrêa, Igor Otavio Minatel\",\"doi\":\"10.36660/abc.20220770\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cardiovascular diseases (CVD) are the major cause of mortality worldwide, whose most prominent risk factor is unhealthy eating habits, such as high fructose intake. Biogenic amines (BAs) perform important functions in the human body. However, the effect of fructose consumption on BA levels is still unclear, as is the association between these and CVD risk factors.</p><p><strong>Objective: </strong>This study aimed to establish the association between BA levels and CVD risk factors in animals that consumed fructose.</p><p><strong>Methods: </strong>Male Wistar rats received standard chow (n=8) or standard chow + fructose in drinking water (30%) (n=8) over a 24-week period. At the end of this period, the nutritional and metabolic syndrome (MS) parameters and plasmatic BA levels were analyzed. A 5% level of significance was adopted.</p><p><strong>Results: </strong>Fructose consumption led to MS, reduced the levels of tryptophan and 5-hydroxitryptophan, and increased histamine. Tryptophan, histamine, and dopamine showed a correlation with metabolic syndrome parameters.</p><p><strong>Conclusion: </strong>Fructose consumption alters BAs associated with CVD risk factors.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2023-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263407/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.36660/abc.20220770\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.36660/abc.20220770","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Background: Cardiovascular diseases (CVD) are the major cause of mortality worldwide, whose most prominent risk factor is unhealthy eating habits, such as high fructose intake. Biogenic amines (BAs) perform important functions in the human body. However, the effect of fructose consumption on BA levels is still unclear, as is the association between these and CVD risk factors.
Objective: This study aimed to establish the association between BA levels and CVD risk factors in animals that consumed fructose.
Methods: Male Wistar rats received standard chow (n=8) or standard chow + fructose in drinking water (30%) (n=8) over a 24-week period. At the end of this period, the nutritional and metabolic syndrome (MS) parameters and plasmatic BA levels were analyzed. A 5% level of significance was adopted.
Results: Fructose consumption led to MS, reduced the levels of tryptophan and 5-hydroxitryptophan, and increased histamine. Tryptophan, histamine, and dopamine showed a correlation with metabolic syndrome parameters.
Conclusion: Fructose consumption alters BAs associated with CVD risk factors.
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