中国社区老年糖尿病患者潜在的药物使用不当。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-10-01 Epub Date: 2023-07-04 DOI:10.1055/a-2123-0734

Xingxing Zhao, Lei Li, Xiujun Guo, Jianqiang Wang, Yingying Yan, Yunyi Le

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引用次数: 0

摘要

背景：可能不合适的药物（PIM）经常被开给患有糖尿病的老年人。本研究旨在评估老年糖尿病患者PIM使用的患病率，并确定影响PIM使用发展的潜在风险因素。方法：这是一项在中国北京门诊进行的横断面研究，采用中国标准。测量门诊环境中老年糖尿病患者PIM使用、多药治疗和合并症的患病率。采用Logistic模型研究多药治疗、合并症和PIM使用之间的相关性。结果：PIM使用和多药治疗的患病率分别为50.1%和70.8%。最常见的合并症是高血压（68.0%）、高脂血症（56.6%）和中风（36.3%），最不适当使用的前三种药物是胰岛素（22.0%）、氯吡格雷（11.9%）和唑匹克隆（9.81%）。年龄（OR 1.025；95%CI 1.009、1.042）、诊断次数（OR 1.172；95%CI 1.114、1.232）、冠心病（OR 1.557；95%CI 1.207、2.009），和多药治疗（OR 1.697；95%CI 1.252，2.301）与PIM的使用有关。结论：鉴于糖尿病老年人PIM使用率较高，需要针对这一人群的策略和干预措施，以尽量减少PIM的使用。

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Potentially Inappropriate Medication Use Among Older Patients with Diabetes in a Chinese Community.

Background: Potentially inappropriate medications (PIMs) are frequently prescribed to older people with diabetes. This study aimed to assess the prevalence of PIM use in older people with diabetes and identify potential risk factors influencing the development of PIM use.

Methods: This was a cross-sectional study conducted in an outpatient setting in Beijing, China, using Chinese criteria. The prevalence of PIM use, polypharmacy, and comorbidities in older adults with diabetes in an outpatient setting was measured. Logistic models were employed to investigate the association among polypharmacy, comorbidities, and PIM use.

Results: The prevalence of PIM use and polypharmacy was 50.1% and 70.8%, respectively. The most common comorbidities were hypertension (68.0%), hyperlipemia (56.6%), and stroke (36.3%), and the top three inappropriately used medications were insulin (22.0%), clopidogrel (11.9%), and eszopiclone (9.81%). Age (OR 1.025; 95% CI 1.009, 1.042), the number of diagnoses (OR 1.172; 95% CI 1.114, 1.232), coronary heart disease (OR 1.557; 95% CI 1.207, 2.009), and polypharmacy (OR 1.697; 95% CI 1.252, 2.301) were associated with PIM use.

Conclusions: Given the higher rate of PIM use among older adults with diabetes, strategies and interventions targeting this population are needed to minimize PIM use.

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来源期刊

Experimental and Clinical Endocrinology & Diabetes 医学-内分泌学与代谢

CiteScore

4.10

自引率

5.60%

发文量

审稿时长

3 months

期刊介绍： Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!