Xiaodan Zhao, Pankaj Garg, Hosamadin Assadi, Ru-San Tan, Ping Chai, Tee Joo Yeo, Gareth Matthews, Zia Mehmood, Shuang Leng, Jennifer Ann Bryant, Lynette L S Teo, Ching Ching Ong, James W Yip, Ju Le Tan, Rob J van der Geest, Liang Zhong
{"title":"主动脉流量与衰老和运动能力有关。","authors":"Xiaodan Zhao, Pankaj Garg, Hosamadin Assadi, Ru-San Tan, Ping Chai, Tee Joo Yeo, Gareth Matthews, Zia Mehmood, Shuang Leng, Jennifer Ann Bryant, Lynette L S Teo, Ching Ching Ong, James W Yip, Ju Le Tan, Rob J van der Geest, Liang Zhong","doi":"10.1093/ehjopen/oead079","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>Increased blood flow eccentricity in the aorta has been associated with aortic (AO) pathology, however, its association with exercise capacity has not been investigated. This study aimed to assess the relationships between flow eccentricity parameters derived from 2-dimensional (2D) phase-contrast (PC) cardiovascular magnetic resonance (CMR) imaging and aging and cardiopulmonary exercise test (CPET) in a cohort of healthy subjects.</p><p><strong>Methods and results: </strong>One hundred and sixty-nine healthy subjects (age 44 ± 13 years, M/F: 96/73) free of cardiovascular disease were recruited in a prospective study (NCT03217240) and underwent CMR, including 2D PC at an orthogonal plane just above the sinotubular junction, and CPET (cycle ergometer) within one week. The following AO flow parameters were derived: AO forward and backward flow indexed to body surface area (FFi, BFi), average flow displacement during systole (FDs<sub>avg</sub>), late systole (FDls<sub>avg</sub>), diastole (FDd<sub>avg</sub>), systolic retrograde flow (SRF), systolic flow reversal ratio (sFRR), and pulse wave velocity (PWV). Exercise capacity was assessed by peak oxygen uptake (PVO<sub>2</sub>) from CPET. The mean values of FDs<sub>avg</sub>, FDls<sub>avg</sub>, FDd<sub>avg</sub>, SRF, sFRR, and PWV were 17 ± 6%, 19 ± 8%, 29 ± 7%, 4.4 ± 4.2 mL, 5.9 ± 5.1%, and 4.3 ± 1.6 m/s, respectively. They all increased with age (<i>r</i> = 0.623, 0.628, 0.353, 0.590, 0.649, 0.598, all <i>P</i> < 0.0001), and decreased with PVO<sub>2</sub> (r = -0.302, -0.270, -0.253, -0.149, -0.219, -0.161, all <i>P</i> < 0.05). A stepwise multivariable linear regression analysis using left ventricular ejection fraction (LVEF), FFi, and FDs<sub>avg</sub> showed an area under the curve of 0.769 in differentiating healthy subjects with high-risk exercise capacity (PVO<sub>2</sub> ≤ 14 mL/kg/min).</p><p><strong>Conclusion: </strong>AO flow haemodynamics change with aging and predict exercise capacity.</p><p><strong>Registration: </strong>NCT03217240.</p>","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460199/pdf/","citationCount":"0","resultStr":"{\"title\":\"Aortic flow is associated with aging and exercise capacity.\",\"authors\":\"Xiaodan Zhao, Pankaj Garg, Hosamadin Assadi, Ru-San Tan, Ping Chai, Tee Joo Yeo, Gareth Matthews, Zia Mehmood, Shuang Leng, Jennifer Ann Bryant, Lynette L S Teo, Ching Ching Ong, James W Yip, Ju Le Tan, Rob J van der Geest, Liang Zhong\",\"doi\":\"10.1093/ehjopen/oead079\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>Increased blood flow eccentricity in the aorta has been associated with aortic (AO) pathology, however, its association with exercise capacity has not been investigated. This study aimed to assess the relationships between flow eccentricity parameters derived from 2-dimensional (2D) phase-contrast (PC) cardiovascular magnetic resonance (CMR) imaging and aging and cardiopulmonary exercise test (CPET) in a cohort of healthy subjects.</p><p><strong>Methods and results: </strong>One hundred and sixty-nine healthy subjects (age 44 ± 13 years, M/F: 96/73) free of cardiovascular disease were recruited in a prospective study (NCT03217240) and underwent CMR, including 2D PC at an orthogonal plane just above the sinotubular junction, and CPET (cycle ergometer) within one week. The following AO flow parameters were derived: AO forward and backward flow indexed to body surface area (FFi, BFi), average flow displacement during systole (FDs<sub>avg</sub>), late systole (FDls<sub>avg</sub>), diastole (FDd<sub>avg</sub>), systolic retrograde flow (SRF), systolic flow reversal ratio (sFRR), and pulse wave velocity (PWV). Exercise capacity was assessed by peak oxygen uptake (PVO<sub>2</sub>) from CPET. The mean values of FDs<sub>avg</sub>, FDls<sub>avg</sub>, FDd<sub>avg</sub>, SRF, sFRR, and PWV were 17 ± 6%, 19 ± 8%, 29 ± 7%, 4.4 ± 4.2 mL, 5.9 ± 5.1%, and 4.3 ± 1.6 m/s, respectively. They all increased with age (<i>r</i> = 0.623, 0.628, 0.353, 0.590, 0.649, 0.598, all <i>P</i> < 0.0001), and decreased with PVO<sub>2</sub> (r = -0.302, -0.270, -0.253, -0.149, -0.219, -0.161, all <i>P</i> < 0.05). A stepwise multivariable linear regression analysis using left ventricular ejection fraction (LVEF), FFi, and FDs<sub>avg</sub> showed an area under the curve of 0.769 in differentiating healthy subjects with high-risk exercise capacity (PVO<sub>2</sub> ≤ 14 mL/kg/min).</p><p><strong>Conclusion: </strong>AO flow haemodynamics change with aging and predict exercise capacity.</p><p><strong>Registration: </strong>NCT03217240.</p>\",\"PeriodicalId\":11973,\"journal\":{\"name\":\"European Heart Journal Open\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460199/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Heart Journal Open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/ehjopen/oead079\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Heart Journal Open","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/ehjopen/oead079","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/7/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Aortic flow is associated with aging and exercise capacity.
Aims: Increased blood flow eccentricity in the aorta has been associated with aortic (AO) pathology, however, its association with exercise capacity has not been investigated. This study aimed to assess the relationships between flow eccentricity parameters derived from 2-dimensional (2D) phase-contrast (PC) cardiovascular magnetic resonance (CMR) imaging and aging and cardiopulmonary exercise test (CPET) in a cohort of healthy subjects.
Methods and results: One hundred and sixty-nine healthy subjects (age 44 ± 13 years, M/F: 96/73) free of cardiovascular disease were recruited in a prospective study (NCT03217240) and underwent CMR, including 2D PC at an orthogonal plane just above the sinotubular junction, and CPET (cycle ergometer) within one week. The following AO flow parameters were derived: AO forward and backward flow indexed to body surface area (FFi, BFi), average flow displacement during systole (FDsavg), late systole (FDlsavg), diastole (FDdavg), systolic retrograde flow (SRF), systolic flow reversal ratio (sFRR), and pulse wave velocity (PWV). Exercise capacity was assessed by peak oxygen uptake (PVO2) from CPET. The mean values of FDsavg, FDlsavg, FDdavg, SRF, sFRR, and PWV were 17 ± 6%, 19 ± 8%, 29 ± 7%, 4.4 ± 4.2 mL, 5.9 ± 5.1%, and 4.3 ± 1.6 m/s, respectively. They all increased with age (r = 0.623, 0.628, 0.353, 0.590, 0.649, 0.598, all P < 0.0001), and decreased with PVO2 (r = -0.302, -0.270, -0.253, -0.149, -0.219, -0.161, all P < 0.05). A stepwise multivariable linear regression analysis using left ventricular ejection fraction (LVEF), FFi, and FDsavg showed an area under the curve of 0.769 in differentiating healthy subjects with high-risk exercise capacity (PVO2 ≤ 14 mL/kg/min).
Conclusion: AO flow haemodynamics change with aging and predict exercise capacity.
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